Inobrodib

(Synonyms: CCS1477)
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression.

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  • Pureté: 99.95%
  • CAS No.: 2222941-37-7
  • Formule: C30H32F2N4O3
  • Masse moléculaire:534.60
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Activité biologique
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100 mg

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