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Cat. No.: HY-14522

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LY 222306

LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a K_i of 0.77 nM.

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CAS No.: 154446-98-7
Formule: C₁₉H₂₃N₅O₇
Masse moléculaire:433.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

LY 222306 Chemical Structure

CAS No.: 154446-98-7

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a K_i of 0.77 nM.

IC₅₀ & Target

Ki: 0.77 nM (GARFT)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	27 nM Compound: 12	In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line	[PMID: 8027993]

Chemical Information

CAS No. 154446-98-7
Masse moléculaire 433.42
Formule C₁₉H₂₃N₅O₇
SMILES

O=C1C2=C(NCC(CCC(O3)=CC=C3C(N[C@@H](CCC(O)=O)C(O)=O)=O)C2)N=C(N)N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Habeck LL, et al. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res. 1994 Feb 15;54(4):1021-6. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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