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Cat. No.: HY-150559

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SMS2-IN-3

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC₅₀=2.2 nM), significantly reduces the hepatic SM (22:0) levels.

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CAS No.: 2414240-89-2
Formule: C₃₃H₃₉F₃N₄O₆
Masse moléculaire:644.68

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SMS2-IN-3 Chemical Structure

CAS No.: 2414240-89-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC₅₀=2.2 nM), significantly reduces the hepatic SM (22:0) levels^[1].

IC₅₀ & Target

IC50: 2.2nM (SMS2)^[1]

Voir tous les produits spécifiques à Isoform Phospholipase :

In Vitro

SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC₅₀= 2.2 nM) and good selectivity against SMS1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

FreeStyle293 cells
Concentration:

100mg/kg
Incubation Time:

60 min
Result:

Showed excellent SMS2 inhibition and good selectivity against SMS1 in biological evaluation.

In Vivo

SMS2-IN-3 (37) has excellent SMS2 activity and high selectivity against SMS1. SMS2-IN-3 also reduces the level of SM by subcutaneous treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KK-Ay/Ta mice^[1]
Dosage:

100, 200 mg/kg
Administration:

SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
Result:

cmpd C_max, (μg/mL) T_max, (h) C_{24 h}, (μg/mL) AUC_0-24(μg•h/mL) MRT(h)

37(p.o.) 6.5 0.83 0.007 18 3.0

37(s.c.) 0.70 8.0 0.23 12 9.4

Chemical Information

CAS No. 2414240-89-2
Masse moléculaire 644.68
Formule C₃₃H₃₉F₃N₄O₆
SMILES

O=C(N1CCC(CCCOC(C2=C(N3C)N=CC=C2)=C(C(N(CC4=CC(OC)=CC(C(F)(F)F)=C4)C)=O)C3=O)CC1)OC5(CC5)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Takafumi Yukawa, et al. Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem. 2020 Apr 1;28(7):115376. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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cmpd	C_max, (μg/mL)	T_max, (h)	C_{24 h}, (μg/mL)	AUC_0-24(μg•h/mL)	MRT(h)
37(p.o.)	6.5	0.83	0.007	18	3.0
37(s.c.)	0.70	8.0	0.23	12	9.4

SMS2-IN-3

Voir tous les produits spécifiques à Isoform Phospholipase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SMS2-IN-3 Related Classifications

HY-150559 Related Classifications