ChoKα inhibitor-4
ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression.
For research use only. We do not sell to patients.
- CAS No.: 2883822-60-2
- Formula: C40H46Br2N6S4
- Molecular Weight:898.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.66 μM (HChoK α1)[1]
ChoKα inhibitor-4 (compound PL55) shows cytotoxicity against NHA from normal human astrocytes with an IC50 value of 2.5 μM[1].
ChoKα inhibitor-4 (1, and 5 μM; 24 h) induces cell cycle block in G1 phase in HeLa and A549 cells[1].
ChoKα inhibitor-4 (1, and 5 μM; 24 h) induces a strong mitochondrial depolarization in HeLa and A549 cells, and (1, and 5 μM; 48 h and 72 h) induces apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2883822-60-2
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Molecular Weight 898.90
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Formula C40H46Br2N6S4
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SMILES
C1(C[N+]2=C3SC=CC3=C(N=C2)N4CCCCCC4)=CC=C(C=C1)SCCSC5=CC=C(C=C5)C[N+]6=CN=C(C7=C6SC=C7)N8CCCCCC8.[Br-].[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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