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Cat. No.: HY-106993AR

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Cipralisant maleate (Standard)

Name: Cipralisant maleate (Standard)
Brand: MedChemExpress
SKU: HY-106993AR
Availability: PreOrder

(Synonyms: GT-2331 maleate (Standard))

Cipralisant maleate (Standard) is the analytical standard of Cipralisant (maleate) (HY-106993A). This product is intended for research and analytical applications. Cipralisant (GT-2331) (maleate) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pK_i of 9.9 for histamine H3 receptor and a K_i of 0.47 nM for rat histamine H3 receptor. Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research. Cipralisant (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 223420-20-0
Formula: C₁₈H₂₄N₂O₄
Molecular Weight:332.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cipralisant maleate (Standard) Chemical Structure

CAS No.: 223420-20-0

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Biological Activity

Description

Cipralisant maleate (Standard) is the analytical standard of Cipralisant (maleate) (HY-106993A). This product is intended for research and analytical applications. Cipralisant (GT-2331) (maleate) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pK_i of 9.9 for histamine H3 receptor and a K_i of 0.47 nM for rat histamine H3 receptor. Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research^[1]^[2]^[3]^[4]. Cipralisant (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

pKi: 9.9 (Histamine H3 receptor)^[4].
Ki: 0.47 nM (Rat histamine H3 receptor)^[5]

All Histamine Receptor Isoforms :

Chemical Information

CAS No. 223420-20-0
Molecular Weight 332.39
Formula C₁₈H₂₄N₂O₄
SMILES

O=C(O)/C=C\C(O)=O.CC(C)(C)CCC#C[C@H]1[C@H](C2=CN=CN2)C1
Synonyms

GT-2331 maleate (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Raddatz R, et al. Histamine H3 antagonists for treatment of cognitive deficits in CNS diseases. Curr Top Med Chem. 2010;10(2):153-169. [Content Brief]

[2]. Fox GB, et al. Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup. Behav Brain Res. 2002;131(1-2):151-161. [Content Brief]

[3]. Ito S, et al. Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor. Eur J Pharmacol. 2006;529(1-3):40-46. [Content Brief]

[4]. Tedford CE, et al. High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models. Eur J Pharmacol. 1998;351(3):307-311. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Cipralisant maleate (Standard)

All Histamine Receptor Isoforms