CypD-IN-4 

CypD-IN-4 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-4 has CypD affinity with an IC₅₀ value of 0.057 μM. CypD-IN-4 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes^[1].

CypD-IN-4 (B53) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC₅₀ values of 0.057 μM, 3.4 μM, 1.1 μM and 0.8 μM, respectively^[1].
CypD-IN-4 (20 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

986.12

C₅₄H₆₃N₇O₁₁

3023438-19-6

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• [1]. Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26.  [Content Brief]