CZS-241 hydrochloride

Cat. No.: HY-149912A Purity: 98.76%: Data Sheet
COA

SDS
Handling Instructions
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CZS-241 hydrochloride is an orally active and selective inhibitor of Polo-like Kinase 4 (PLK4) (IC₅₀=2.6 nM). CZS-241 hydrochloride inhibits TRKA with an IC₅₀ value of 2.74 μM. CZS-241 hydrochloride induces apoptosis and arrests cell cycle at S/G2 phase. CZS-241 hydrochloride shows highly potent antiproliferative activity against leukemia cell lines, and exhibits safety against normal cell lines.

For research use only. We do not sell to patients.

CZS-241 hydrochloride Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CZS-241 hydrochloride:

CZS-241 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Polo-like Kinase (PLK) Isoform Specific Products:

View All Isoforms

PLK1 PLK2 PLK3 PLK4

View All Trk Receptor Isoform Specific Products:

View All Isoforms

TrkA TrkB TrkC Trk

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

588.44

Formula

C₂₆H₂₅Cl₂F₂N₉O

Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C=C1NC(C2=C(C=CC(CNC3=NC4=C(C(NC5=NNC(C)=C5)=N3)C=NN4C(C)C)=C2)Cl)=O)F.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 60.6 mg/mL (102.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6994 mL	8.4970 mL	16.9941 mL
5 mM	0.3399 mL	1.6994 mL	3.3988 mL
10 mM	0.1699 mL	0.8497 mL	1.6994 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Sun Y, et al. Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia. J Med Chem. 2023 Feb 23;66(4):2396-2421. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6994 mL	8.4970 mL	16.9941 mL	42.4852 mL
	5 mM	0.3399 mL	1.6994 mL	3.3988 mL	8.4970 mL
	10 mM	0.1699 mL	0.8497 mL	1.6994 mL	4.2485 mL
	15 mM	0.1133 mL	0.5665 mL	1.1329 mL	2.8323 mL
	20 mM	0.0850 mL	0.4249 mL	0.8497 mL	2.1243 mL
	25 mM	0.0680 mL	0.3399 mL	0.6798 mL	1.6994 mL
	30 mM	0.0566 mL	0.2832 mL	0.5665 mL	1.4162 mL
	40 mM	0.0425 mL	0.2124 mL	0.4249 mL	1.0621 mL
	50 mM	0.0340 mL	0.1699 mL	0.3399 mL	0.8497 mL
	60 mM	0.0283 mL	0.1416 mL	0.2832 mL	0.7081 mL
	80 mM	0.0212 mL	0.1062 mL	0.2124 mL	0.5311 mL
	100 mM	0.0170 mL	0.0850 mL	0.1699 mL	0.4249 mL