DBCO-NHCO-PEG6-Biotin

Name: DBCO-NHCO-PEG6-Biotin
Brand: MedChemExpress
SKU: HY-135958
Rating: 4.5 (0 reviews)

製品番号: HY-135958 純度: 96.65%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

DBCO-NHCO-PEG6-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG6-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-NHCO-PEG6-Biotin 構造式

CAS 番号 : 3081794-36-4

容量	価格（税別）	在庫状況	数量
5 mg	$120	在庫あり	Estimated Time of Arrival: December 31
10 mg	$190	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of DBCO-NHCO-PEG6-Biotin:

DBCO-NHCO-PEG2-Biotin 在庫あり

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

DBCO-NHCO-PEG6-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. DBCO-NHCO-PEG6-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

838.02

分子式

C₄₃H₅₉N₅O₁₀S

CAS 番号

3081794-36-4

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(N1)N[C@](CS2)([H])[C@@]1([H])[C@@H]2CCCCC(NCCOCCOCCOCCOCCOCCOCCC(NCCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (59.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1933 mL	5.9664 mL	11.9329 mL
5 mM	0.2387 mL	1.1933 mL	2.3866 mL
10 mM	0.1193 mL	0.5966 mL	1.1933 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 96.65%

Select Batch:

データシート (267 KB) SDS (394 KB)

COA (242 KB) HNMR (376 KB) RP-HPLC (266 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1933 mL	5.9664 mL	11.9329 mL	29.8322 mL
	5 mM	0.2387 mL	1.1933 mL	2.3866 mL	5.9664 mL
	10 mM	0.1193 mL	0.5966 mL	1.1933 mL	2.9832 mL
	15 mM	0.0796 mL	0.3978 mL	0.7955 mL	1.9888 mL
	20 mM	0.0597 mL	0.2983 mL	0.5966 mL	1.4916 mL
	25 mM	0.0477 mL	0.2387 mL	0.4773 mL	1.1933 mL
	30 mM	0.0398 mL	0.1989 mL	0.3978 mL	0.9944 mL
	40 mM	0.0298 mL	0.1492 mL	0.2983 mL	0.7458 mL
	50 mM	0.0239 mL	0.1193 mL	0.2387 mL	0.5966 mL