BTK-IN-19
BTK-IN-19 (Compound 51) is a reversible BTK inhibitor with an IC50 of <0.001 μM.
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- CAS. Nr.: 1374240-01-3
- Formel: C21H22Cl2N6O
- Molecular Weight:445.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: <0.001 μM (BTK)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| B-cell | IC50 |
0.08 μM
Compound: 51
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Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4
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[PMID: 36538993] |
In Vitro
BTK-IN-19 (Compound 51) inhibits B cell proliferation with IC50 of 0.080 μM (3 d)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:B cells enriched from PBMC
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Concentration:
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Incubation Time:3 days
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Result:Inhibited B-cell proliferation with an IC50 of 0.080 μM.
In Vivo
BTK-IN-19 (5 mg/kg; p.o.) demonstrates low-moderate in vivo clearance and modest oral exposure (%F > 34) in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1 mice[1]
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Dosage:80 mg/kg
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Administration:IP, once
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Result:Demonstrated strong inhibition of CD69.
Chemical Information
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CAS. Nr. 1374240-01-3
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Molecular Weight 445.34
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Formel C21H22Cl2N6O
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SMILES
ClC1=CC(Cl)=CC(NCC(N2C[C@]3([H])N(C4=C5C(NC=C5)=NC=N4)CC[C@]3([H])CC2)=O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BTK-IN-19 Related Classifications
HY-152212 Related Classifications
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