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Art. -Nr.: HY-187640

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CRM-51005

CRM-51005 is a phospholipase C (PLC)γ1 inhibitor with a bovine IC₅₀ of 13.0 μg/mL. CRM-51005 inhibits PLCγ1 enzymatic activity and platelet-derived growth factor-induced phosphoinositide turnover. CRM-51005 acts as a cell growth inhibitor via suppression of PLC, phosphoinositide turnover, DNA synthesis, and cell proliferation.

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CAS. Nr.: 203051-01-8
Formel: C₁₅H₂₀O₃
Molecular Weight:248.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRM-51005 Chemical Structure

CAS. Nr.: 203051-01-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PLCγ1

13 μg/mL (IC₅₀)

Alle Phospholipase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC50	0.8 μg/mL	Inhibition of PDGF-induced total inositol phosphates formation in NIH3T3γ1 cells; cells were prelabelled with myo-[2-³H]-inositol for 24 hours, preincubated in 20 mM LiCl for 15 minutes, treated with CRM-51005 for 10 minutes, then stimulated with PDGF for 30 minutes, with IPₜ extracted and measured via Biorad AG 1-X8 anion exchange column. Inhibition of PDGF-induced total inositol phosphates formation in NIH3T3γ1 cells; cells were prelabelled with myo-[2-³H]-inositol for 24 hours, preincubated in 20 mM LiCl for 15 minutes, treated with CRM-51005 for 10 minutes, then stimulated with PDGF for 30 minutes, with IPₜ extracted and measured via Biorad AG 1-X8 anion exchange column.	9510921

In Vitro

CRM-51005 inhibits purified bovine cerebellum PLCγ1 enzyme activity with an IC₅₀ of 13.0 μg/mL^[1].
CRM-51005 (10 min) inhibits PDGF-induced total inositol phosphates formation in NIH3T3γ1 cells with an IC₅₀ of 0.8 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 203051-01-8
Molecular Weight 248.32
Formel C₁₅H₂₀O₃
SMILES

CCC/C=C(C1=C(C(O)=C(C(O)=C1)CC)C=O)\C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Oh WK, et al. CRM-51005, a new phospholipase C inhibitor produced by unidentified fungal strain MT51005. J Antibiot (Tokyo). 1997 Dec;50(12):1083-5.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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