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Art. -Nr.: HY-157040

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MAGL-IN-9

MAGL-IN-9 (compound 16) is a selective and reversible MAGL inhibitor with IC₅₀ 2.7 nM.

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CAS. Nr.: 3017151-74-2
Formel: C₂₅H₂₂F₄N₂O₂S
Molecular Weight:490.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

MAGL-IN-9 Chemical Structure

CAS. Nr.: 3017151-74-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MAGL-IN-9 (compound 16) is a selective and reversible MAGL inhibitor with IC₅₀ 2.7 nM^[1].

IC₅₀ & Target

IC50: 2.7 nM (MAGL)^[1]

In Vitro

MAGL-IN-9 (10 μM, 25 min) selectively inhibits MAGL in mouse brain membrane preparations, without affecting other serine hydrolases such as FAAH, ABHD6, and ABHD12^[1].
MAGL-IN-9 shows a reversible inhibition mechanism in both preincubation and dilution tests^[1].
MAGL-IN-9 inhibits MAGL in U973 cells with an IC₅₀ value of 193 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3017151-74-2
Molecular Weight 490.51
Formel C₂₅H₂₂F₄N₂O₂S
SMILES

O=C(N1CCC(CC2=CC=C(F)C(SC3=NC=CC(C(F)(F)F)=C3)=C2)CC1)C4=CC=CC(O)=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Di Stefano M, et al. Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors[J]. European Journal of Medicinal Chemistry, 2023: 115916. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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