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Art. -Nr.: HY-P9944

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Biologically Validated

Palivizumab

Name: Palivizumab
Brand: MedChemExpress
SKU: HY-P9944
Price: 280.00 USD
Availability: InStock
Rating: 5 (3 reviews)

(Synonyms: MEDI 493)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a K_d value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.63%
CAS. Nr.: 188039-54-5
Molecular Weight:145.5 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Palivizumab Chemical Structure

CAS. Nr.: 188039-54-5

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

RSV-F

In Vitro

Palivizumab has RSV neutralizing activity and an EC₅₀ value of 0.95850 nM with IgG1 protein^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Palivizumab (0.625-5 mg/kg (i.m.) or 0.312-10 mg/kg (i.v.); single dose) can prevent respiratory syncytial virus infection in cotton mice^[1].
Palivizumab (0.05 mg/kg; single dose; intranasally administered)can prevent RSV infection in mice^[2].
Palivizumab (15 mg/kg; single dose; s.c.) can inhibit RSV induced airway neurogenic inflammation in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

The cotton rat model of RSV infection^[1].
Dosage:

0.625-5 mg/kg (i.m.) or 0.312-10 mg/kg (i.v.)
Administration:

Intramuscular injection (i.m.) or intravenous injection (i.v.); single dose
Result:

Reduced virus replication and did not cause RSV infection or pathological increase in both initial and secondary attacks.

Animal Model:

BALB/c mice^[2].
Dosage:

0.05 mg/kg
Administration:

Intranasally administered; single dose
Result:

Reduced the RSV load.

Animal Model:

Capsaicin-induced neurogenic inflammation in the airways of rats^[3].
Dosage:

15 mg/kg
Administration:

Subcutaneous injection (s.c.); single dose
Result:

Reduced neurogenic extravasation and neurogenic inflammation.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Accession

A0A0X8XRK2

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human respiratory syncytial virus (RSV) Prefusion glycoprotein F can bind Palivizumab. The EC₅₀ for this effect is 2.043 ng/mL.

Chemical Information

CAS. Nr. 188039-54-5
Appearance Liquid
Molecular Weight 145.5 kDa
Color Colorless to light yellow
SMILES

[Palivizumab]
Synonyms

MEDI 493
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All

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Journal Impact Factor

Int Immunopharmacol

An oral vaccine based on the Ad5 vector with a double-stranded RNA adjuvant protects mice against respiratory syncytial virus. [Abstract]

2025 Jan 27:146:113970. PMID: 39736241
Bioconjug Chem

Resin-Supported Site-Specific Antibody Conjugation Method Leads to Antibody-Drug Conjugates with Retained Efficacy and Improved Stability. [Abstract]

2025 Aug 21. PMID: 40839643
Npj Viruses

STAT1 signaling controls cholesterol metabolism in epithelial cells and RSV-induced syncytia formation. [Abstract]

2026 Feb 16;4(1):10. PMID: 41699197

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Johnson S, et al. Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus. J Infect Dis. 1997 Nov;176(5):1215-24. [Content Brief]

[2]. Jacobino SR, et al. Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo. MAbs. 2018 Apr;10(3):453-462. [Content Brief]

[3]. Piedimonte G, et al. A humanized monoclonal antibody against respiratory syncytial virus (palivizumab) inhibits RSV-induced neurogenic-mediated inflammation in rat airways. Pediatr Res. 2000 Mar;47(3):351-6. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Palivizumab

3 Cited Publications

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise

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Palivizumab

Publications Citing Use of MedChemExpress (MCE) Palivizumab