2. Anti-infection
  3. RSV
  4. Motavizumab

Motavizumab  (Synonyms: MEDI-524)

Cat. No.: HY-P99209 Purity: 98.35%
COA

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Motavizumab (MEDI-524) is an anti-human RSV (respiratory syncytial virus) monoclonal antibody. Motavizumab can be used in respiratory syncytial virus infection in high-risk infants research.

For research use only. We do not sell to patients.

Motavizumab Chemical Structure

Motavizumab Chemical Structure

CAS No. : 677010-34-3

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Based on 1 publication(s) in Google Scholar

Motavizumab Related Antibodies

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Description

Motavizumab (MEDI-524) is an anti-human RSV (respiratory syncytial virus) monoclonal antibody. Motavizumab can be used in respiratory syncytial virus infection in high-risk infants research[1].

In Vitro

Motavizumab shows activity after F protein initiates interaction with the cell membrane and before virus transcription[2].
Motavizumab inhibits F protein-mediated cell-to-cell fusion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Motavizumab Related Antibodies
In Vivo

Motavizumab (intraperitoneal injection; 1.25 mg in 0.1 ml of PBS/per mouse; once) treatment shows reductions on RSV replication and concentrations of cytokine and chemokines in RSV-infected mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old female, pathogen-free BALB/c mice intranasally inoculated with 106.5 PFU RSV-A2[1]
Dosage: 1.25 mg in 0.1 ml of PBS/per mouse
Administration: Intraperitoneal injection; 1.25 mg in 0.1 ml of PBS/per mouse; once
Result: Resulted in significant reductions of RSV loads compared with untreated controls on days 1 and 5.
Showed lower BAL concentrations of IL-1α, IL-12p70, TNF-α and IFN-γ and serum IL-10 and KC compared with RSV-infected untreated mice.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Motavizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.35%

COA (291 KB)

Handling Instructions (2659 KB)
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Motavizumab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Motavizumab677010-34-3MEDI-524MEDI524MEDI 524RSVRespiratory syncytial virusrespiratory syncytial virus infection in high-risk infantsInhibitorinhibitorinhibit

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