The in vivo activity of olamufloxacin (HSR-903) in systemic and urinary tract infections in mice

  • J Antimicrob Chemother. 2001 Jul;48(1):137-40. doi: 10.1093/jac/48.1.137.
S Yoshizumi  1 ,  Y Takahashi ,  M Murata ,  H Domon ,  N Furuya ,  Y Ishii ,  T Matsumoto ,  A Ohno ,  K Tateda ,  S Miyazaki ,  K Yamaguchi
Affiliations
  • 1. Department of Microbiology, Toho University School of Medicine, Tokyo. Research Department, Research & Development Division, Hokuriku Seiyaku Co., Ltd, Fukui, Japan. [email protected]
PMID: 11418525 DOI: 10.1093/jac/48.1.137
Abstract

The in vivo activity of olamufloxacin (HSR-903), a new fluoroquinolone, was evaluated and compared with ciprofloxacin, sparfloxacin and levofloxacin. Olamufloxacin was active against systemic Infection in mice inoculated with both Gram-positive and -negative bacteria. Olamufloxacin had equal efficacy for experimental Urinary Tract Infections in mice caused by Pseudomonas aeruginosa.

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