3053402-10-8
3053402-10-8
Chemical Structure
HDAC6-IN-84
- CAS No.: 3053402-10-8
- Formula:C17H16N2O3S
- Molecular Weight:328.39
InChIKey: IEZACFUZGSDTHH-UHFFFAOYSA-N
SMILES: O=C(NO)CCC1=CSC(C2=CC=C3C=C(OC)C=CC3=C2)=N1
Biological Activity: HDAC6-IN-84 is a potent and selective HDAC6 inhibitor with an IC50 of 25.56 nM and shows 478-fold selectivity over HDAC1. HDAC6-IN-84 increases α-tubulin acetylation and upregulates BDNF (exons I and IV) and other neurogenesis-related genes. HDAC6-IN-84 can be used for the study of Alzheimer’s disease (AD) and other neurodegenerative diseases[1].
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HDAC6-IN-84 | HDAC6-IN-84 is a potent and selective HDAC6 inhibitor with an IC50 of 25.56 nM and shows 478-fold selectivity over HDAC1. HDAC6-IN-84 increases α-tubulin acetylation and upregulates BDNF (exons I and IV) and other neurogenesis-related genes. HDAC6-IN-84 can be used for the study of Alzheimer’s disease (AD) and other neurodegenerative diseases. | |||||||||||||||||||||
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