Chemical Constituents of the Deep-Sea-Derived Penicillium limosum ZEN48 and Their Osteoclasts' Inhibitory Activity

  • Chem Biodivers. 2026 Mar;23(3):e03812. doi: 10.1002/cbdv.202503812.
Yong Zhang  1  2  3 ,  Yan-Qing Guo  1 ,  You Li  1 ,  Zheng-Biao Zou  1 ,  Tai-Zong Wu  3 ,  Chun-Lan Xie  2 ,  Xian-Wen Yang  1
Affiliations
  • 1. Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China.
  • 2. Key Laboratory of Tropical Translational Medicine of the Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China.
  • 3. Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, China.
PMID: 41838563 DOI: 10.1002/cbdv.202503812
Abstract

Three previously undescribed compounds (1-3), including an unusual pyridazine derivative, one sesquiterpenoid, and a polyketide with novel stereochemistry, together with 24 known compounds (4-27), were isolated from the deep-sea-derived Penicillium limosum ZEN48. The structures of the new compounds were elucidated by comprehensive analyses of one- and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and optical rotation calculation. Compounds 13, 18, and 19 exhibited considerable inhibitory effect in osteoclast formation at 20 µM in bone marrow-derived monocytes, indicating their potential application in anti-osteoporotic therapy.

Keywords
Penicillium limosum; chemical constituents; deep‐sea; fungus; osteoclasts.
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