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Cat. No.: HY-W1058144

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Dibutyltin bis(2-ethylhexanoate)

Dibutyltin bis (2-ethylhexanoate) is an orally active metal-based catalyst with cytotoxicity, and exhibits acute oral toxicity in white-footed mice.

For research use only. We do not sell to patients.

CAS No.: 2781-10-4
Formula: C₂₄H₄₈O₄Sn
Molecular Weight:519.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dibutyltin bis(2-ethylhexanoate) Chemical Structure

CAS No.: 2781-10-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Dibutyltin bis (2-ethylhexanoate) is an orally active metal-based catalyst with cytotoxicity, and exhibits acute oral toxicity in white-footed mice^[1].

In Vitro

Dibutyltin bis(2-ethylhexanoate) (0.8-200 μM; 24 h) exhibits strong cytotoxicity against human fetal intestinal epithelial cells FHs74Int, with an IC₅₀ of 3.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

FHs74Int fetal human intestinal epithelial cells
Concentration:

0.8-200 μM
Incubation Time:

24 h
Result:

Reduced FHs74Int cell viability sharply at low concentrations, approaching 0% at concentrations above 10 μM.
Achieved an IC₁₀ of 2.5 μM, IC₅₀ of 3.1 μM, and IC₉₀ of 4.2 μM.

In Vivo

Dibutyltin bis(2-ethylhexanoate) (62-1075 mg/kg; p.o.; single acute administration, repeated daily administration) exhibits an approximate acute oral lethal dose of 1075 mg/kg and a daily LD₅₀ of 62 mg/kg/day in deer mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Deer mice^[1]
Dosage:

1075 mg/kg (acute); 62 mg/kg/day (repeated)
Administration:

p.o.; single acute dose; daily repeated dose
Result:

Determined an acute oral approximate lethal dose of 1075 mg/kg.
Identified a repeated daily LD₅₀ dose of 62 mg/kg/day.

Chemical Information

CAS No. 2781-10-4
Molecular Weight 519.35
Formula C₂₄H₄₈O₄Sn
SMILES

O=C(O[Sn](OC(=O)C(CC)CCCC)(CCCC)CCCC)C(CC)CCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nachtergael A, et al. Organocatalysis paradigm revisited: are metal-free catalysts really harmless?. Biomacromolecules. 2015 Feb 09;16(2):507-14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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