Dihydroconiferyl dihydro-p-coumarate
Dihydroconiferyl dihydro-p-coumarate is a mesophenolic acetylcholinesterase (AChE) inhibitor discovered in orchids such as Vanda roxburghii and Dendrobium nobile, with an IC50 of 118.17 μg/mL against mouse AChE. Dihydroconiferyl dihydro-p-coumarate reduces the hydrolytic activity of AChE, scavenges DPPH and hydroxyl radicals, exhibits potassium ferricyanide reducing power, reduces Mo (VI) to Mo (V), and inhibits lipid peroxidation in mouse brain homogenates. Dihydroconiferyl dihydro-p-coumarate is a key hypoglycemic compound and shows no significant cytotoxicity to human cancer cells. Dihydroconiferyl dihydro-p-coumarate can be used in research related to Alzheimer's disease and type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 152543-09-4
- Formula: C19H22O5
- Molecular Weight:330.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
AChE 118.17 μg/mL (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SGC-7901 | IC50 |
>30 μM
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Cytotoxicity against human gastric carcinoma SGC-7901 cells by MTT method.
Cytotoxicity against human gastric carcinoma SGC-7901 cells by MTT method.
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33855299 |
| Bel-7402 | IC50 |
>30 μM
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Cytotoxicity against human hepatocellular carcinoma BEL-7402 cells by MTT method.
Cytotoxicity against human hepatocellular carcinoma BEL-7402 cells by MTT method.
|
33855299 |
| K562 | IC50 |
>30 μM
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Cytotoxicity against human chronic myelogenous leukemia K562 cells by MTT method.
Cytotoxicity against human chronic myelogenous leukemia K562 cells by MTT method.
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33855299 |
In Vitro
Dihydroconiferyl dihydro-p-coumarate (compound 10) exhibits an IC50 value of >30 μM against the human cancer cell lines SGC-7901, BEL-7402, and K562, and shows no detectable cytotoxicity[1].
Dihydroconiferyl dihydro-p-coumarate (6.25-100 μg/mL; 15 min) inhibits mouse brain acetylcholinesterase, with an IC50 of 118.17 μg/mL[2].
Dihydroconiferyl dihydro-p-coumarate (6.25-100 μg/mL; 30 min) exhibits DPPH free radical scavenging activity, with an IC50 of 12.16 μg/mL[2].
Dihydroconiferyl dihydro-p-coumarate (1 h) scavenges hydroxyl radicals generated in vitro[2].
Dihydroconiferyl dihydro-p-coumarate (10-80 μg/mL; 20 min) exhibits concentration-dependent ferric-reducing antioxidant capacity, with an absorbance of 0.894 at high concentrations[2].
Dihydroconiferyl dihydro-p-coumarate (10-80 μg/mL; 90 min) exhibits a concentration-dependent total antioxidant capacity (reducing Mo (VI) to Mo (V)), with an absorbance of 0.735 at high concentrations[2].
Dihydroconiferyl dihydro-p-coumarate (6.25-100 μg/mL) effectively inhibits Fe2+-ascorbic acid-induced lipid peroxidation in mouse brain homogenate, with an IC50 of 44.20 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 152543-09-4
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Molecular Weight 330.38
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Formula C19H22O5
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SMILES
O=C(OCCCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydroconiferyl dihydro-p-coumarate Related Classifications
HY-N21789 Related Classifications
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