152543-09-4
Chemical Structure
Dihydroconiferyl dihydro-p-coumarate
- CAS No.: 152543-09-4
- Formula:C19H22O5
- Molecular Weight:330.38
IUPAC Name: 3-(4-hydroxy-3-methoxyphenyl)propyl 3-(4-hydroxyphenyl)propanoate
InChIKey: ZXQHQUXJMNGVJP-UHFFFAOYSA-N
SMILES: O=C(OCCCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C=C2
Biological Activity: Dihydroconiferyl dihydro-p-coumarate is a mesophenolic acetylcholinesterase (AChE) inhibitor discovered in orchids such as Vanda roxburghii and Dendrobium nobile, with an IC50 of 118.17 μg/mL against mouse AChE. Dihydroconiferyl dihydro-p-coumarate reduces the hydrolytic activity of AChE, scavenges DPPH and hydroxyl radicals, exhibits potassium ferricyanide reducing power, reduces Mo (VI) to Mo (V), and inhibits lipid peroxidation in mouse brain homogenates. Dihydroconiferyl dihydro-p-coumarate is a key hypoglycemic compound and shows no significant cytotoxicity to human cancer cells. Dihydroconiferyl dihydro-p-coumarate can be used in research related to Alzheimer's disease and type 2 diabetes[1][2][3][4].
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Dihydroconiferyl dihydro-p-coumarate | Dihydroconiferyl dihydro-p-coumarate is a mesophenolic acetylcholinesterase (AChE) inhibitor discovered in orchids such as Vanda roxburghii and Dendrobium nobile, with an IC50 of 118.17 μg/mL against mouse AChE. Dihydroconiferyl dihydro-p-coumarate reduces the hydrolytic activity of AChE, scavenges DPPH and hydroxyl radicals, exhibits potassium ferricyanide reducing power, reduces Mo (VI) to Mo (V), and inhibits lipid peroxidation in mouse brain homogenates. Dihydroconiferyl dihydro-p-coumarate is a key hypoglycemic compound and shows no significant cytotoxicity to human cancer cells. Dihydroconiferyl dihydro-p-coumarate can be used in research related to Alzheimer's disease and type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Chen X J, et al. Four new bibenzyl derivatives from Dendrobium sinense[J]. Phytochemistry letters, 2014, 9: 107-112.
- [2]. Ahammed S, et al. Acetylcholinesterase Inhibitory and Antioxidant Activity of the Compounds Isolated from Vanda roxburghii. Adv Pharmacol Pharm Sci. 2021 Mar 27;2021:5569054.
- [3]. Fang YS, et al. New phenylpropanoids from Bulbophyllum retusiusculum. Archives of pharmacal research. 2018 Nov;41(11):1074-1081.
- [4]. Li Z, et al. Chemical Constituents and Hypoglycemic Mechanisms of in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification. Molecules (Basel, Switzerland). 2023 Mar 16;28(6):2683.
