DMG-PEG2000-R8

DMG-PEG2000-R8 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. R8 peptide: Targeting/functional ligand-R8 peptide (octaarginine) is a cationic cell-penetrating peptide (CPP) that mediates carrier entry into cells through positive-charge interaction with the negative charge on the cell membrane surface, effectively enhancing cellular uptake efficiency.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .