LUC7L - LUC7 like Gene

Also Known as Luc7; SR+89; LUC7B1; hLuc7B1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55692

About LUC7L

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:188,990-229,449 (from NCBI)

This gene has 21 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 18.6), spleen (RPKM 15.0) and 25 other tissues.

Summary

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]

LUC7L Products (4)

mRNA Protein Name
NM_001320226.2 NP_001307155.1 putative RNA-binding protein Luc7-like 1 isoform a
NM_001330420.2 NP_001317349.1 putative RNA-binding protein Luc7-like 1 isoform c
NM_018032.5 NP_060502.1 putative RNA-binding protein Luc7-like 1 isoform a
NM_201412.3 NP_958815.1 putative RNA-binding protein Luc7-like 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LUC7L Protein Structure

LUC7

LUC7: LUC7 N_terminus (5 - 247)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

putative RNA-binding protein Luc7-like 1

  • putative SR protein LUC7B1

LUC7L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LUC7L Q9NQ29 RNASEH1 Homo sapiens O60930
Anti Tag CoIP
33961781
Intra
LUC7L Q9NQ29 NFKBIL1 Homo sapiens Q9UBC1
Anti Tag CoIP
33961781
Intra
LUC7L Q9NQ29 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra
LUC7L Q9NQ29 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra
LUC7L Q9NQ29 SRPK1 Homo sapiens Q96SB4
Protein Kinase Assay
23602568
Intra
LUC7L Q9NQ29 CLK2 Homo sapiens P49760
Anti Tag CoIP
33961781
Intra
LUC7L Q9NQ29 TNPO3 Homo sapiens Q9Y5L0
Anti Tag CoIP
33961781
Intra
LUC7L Q9NQ29 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
LUC7L Q9NQ29 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
LUC7L Q9NQ29 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alpha-Thalassemia

  • Alpha Thalassemia

  • Alpha Thalassaemia

  • Alpha Plus Thalassemia

  • Thalassemia, Alpha-

  • Thalassemias, Alpha-

  • A-Thalassemia

  • Α-Thalassemia

  • A-THAL

  • Thalassemia

  • Alpha Thalassaemia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07888 LUC7L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07889 LUC7L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07890 LUC7L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LUC7L MGD MGI:1914228
Canis familiaris LUC7L VGNC VGNC:42863
Bos taurus LUC7L VGNC VGNC:31079
Rattus norvegicus LUC7L RGD RGD:1307542
Macaca mulatta LUC7L VGNC VGNC:74461
Felis catus LUC7L VGNC VGNC:80589
Others LUC7L NCBI