MLLT10 - MLLT10 histone lysine methyltransferase DOT1L cofactor Gene

Also Known as AF10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8028

About MLLT10

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:21,533,756-21,743,630 (from NCBI)

This gene has 26 transcripts (splice variants), 221 orthologues, 8 paralogues and is associated with 81 phenotypes. Broad expression in testis (RPKM 40.9), ovary (RPKM 8.6) and 23 other tissues.

Summary

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

MLLT10 Products (7)

mRNA Protein Name
NM_001195626.3 NP_001182555.1 protein AF-10 isoform c
NM_001195627.2 NP_001182556.1 protein AF-10 isoform d
NM_001195628.2 NP_001182557.1 protein AF-10 isoform e
NM_001195630.2 NP_001182559.1 protein AF-10 isoform e
NM_001324296.2 NP_001311225.1 protein AF-10 isoform e
NM_001324297.2 NP_001311226.1 protein AF-10 isoform f
NM_004641.4 NP_004632.1 protein AF-10 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
26439302 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
26439302 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
26439302 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17868029 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17868029 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15851025 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
15851025 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLLT10 Protein Structure

PHD_2

PHD_2: PHD-finger (37 - 72)

zf-HC5HC2H_2

zf-HC5HC2H_2: PHD-zinc-finger like domain (81 - 197)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1068 a.a.
Protein Preferred Names Protein Names

protein AF-10

  • ALL1-fused gene from chromosome 10 protein

MLLT10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MLLT10 P55197 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
20203130
Intra
MLLT10 P55197 CTNNB1 Homo sapiens P35222
Pull Down
21103407
Intra
MLLT10 P55197 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21103407
Cross: Cross-species interaction Intra: Intraspecies interaction

MLLT10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82272 AF10 Antibody (YA2017) WB, IHC-P Human
HY-P82272A AF10 Antibody (YA2017)(PBS only) WB, IHC-P Human

Related Diseases

Diseases Alias
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Leukemia, Acute Monocytic

  • Acute Monocytic Leukemia

  • Acute Monoblastic Leukemia And Acute Monocytic Leukemia

  • Acute Monocytic Leukaemia

  • Acute Monocytic Leukaemia Without Mention Of Remission

  • Acute Monocytic Leukemia Without Mention Of Remission

  • Acute Monocytic Leukemia, Fab M5

  • Acute Monocytic Leukemia, Morphology

  • Leukemia, Monocytic, Acute

  • M5b Acute Differentiated Monocytic Leukemia
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Neoplasms

  • Hematologic Malignancies

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Mixed Phenotype Acute Leukemia, T/Myeloid

  • Doid:0081039
Childhood Leukemia
Childhood Acute Myeloid Leukemia

  • Childhood Acute Myeloid Leukaemia

  • Paediatric Acute Myeloid Leukaemia

  • Pediatric Acute Myeloid Leukemia
Acute Biphenotypic Leukemia

  • Mixed Phenotype Acute Leukemia

  • Acute Leukemia Of Ambiguous Lineage

  • Acute Undifferentiated Leukemia

  • Acute Leukemia Of Indeterminate Lineage

  • Hybrid Acute Leukemia

  • Mixed Lineage Acute Leukemia

  • All With Myeloid Markers

  • Aml With Lymphoid Markers

  • Acute Leukemia Of Undetermined Lineage

  • Bal

  • Biphenotypic Acute Leukemia

  • Undifferentiated Acute Leukemia

  • Mpal

  • Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

  • Leukemia, Biphenotypic, Acute
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08494 MLLT10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21886 Mllt10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28403 Mllt10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MLLT10 VGNC VGNC:58389
Mus musculus MLLT10 MGD MGI:1329038
Canis familiaris MLLT10 VGNC VGNC:50637
Felis catus MLLT10 VGNC VGNC:63524
Rattus norvegicus MLLT10 RGD RGD:1310874
Others MLLT10 NCBI