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Cat. No.: HY-U00050S

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(E)-10-Hydroxynortriptyline-d₃

Name: (E)-10-Hydroxynortriptyline-d3
Brand: MedChemExpress
SKU: HY-U00050S
Price: 790.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: E-10-OH-NT-d₃)

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Based on 1 Customer Validation

(E)-10-Hydroxynortriptyline-d₃ (E-10-OH-NT-d₃) is the deuterated-labeled (E)-10-Hydroxynortriptyline (HY-U00050). (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression.

For research use only. We do not sell to patients.

Purity: 99.65%
Formula: C₁₉H₁₈D₃NO
Molecular Weight:282.39

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

(E)-10-Hydroxynortriptyline-d₃ Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Adrenergic Receptor Isoforms :

All mAChR Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 47132-16-1
Appearance Solid
Molecular Weight 282.39
Formula C₁₉H₁₈D₃NO
Color White to off-white
SMILES

OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC([2H])([2H])[2H]
Synonyms

E-10-OH-NT-d₃
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nordin C, et al. Little anticholinergic effect of E-10-hydroxynortriptyline compared with nortriptyline in healthy subjects. Clin Pharmacol Ther. 1987;41(1):97-102. [Content Brief]

[2]. Bertilsson L, et al. E-10-hydroxynortriptyline: effects and disposition of a potential novel antidepressant[J]. Clinical Pharmacology in Psychiatry: From Molecular Studies to Clinical Reality, 1989: 52-59.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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(E)-10-Hydroxynortriptyline-d3

All Adrenergic Receptor Isoforms

All mAChR Isoforms