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Cat. No.: HY-172937

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ERα degrader 13

ERα degrader 13 (compound MR3) is potent ERα degrader with an IC₅₀ of 0.55 μM. ERα degrader 13 induces an obvious tumor regression in the breast cancer xenograft mouse model.

For research use only. We do not sell to patients.

CAS No.: 3070968-56-5
Formula: C₅₀H₄₈N₄O₅S₂
Molecular Weight:849.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

ERα degrader 13 Chemical Structure

CAS No.: 3070968-56-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

ERα degrader 13 (compound MR3) is potent ERα degrader with an IC₅₀ of 0.55 μM. ERα degrader 13 induces an obvious tumor regression in the breast cancer xenograft mouse model^[1].

All Estrogen Receptor/ERR Isoforms :

Chemical Information

CAS No. 3070968-56-5
Molecular Weight 849.07
Formula C₅₀H₄₈N₄O₅S₂
SMILES

CCN(C1=CC=C2N=C(C(SC2=C1)=C/C3=N/CCCCCCC(NCCOC4=CC=C(C=C4)C(C5=C(SC6=C5C=CC(O)=C6)C7=CC=C(C=C7)O)=O)=O)C8=C3C=CC=C8)CC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Rational Design of Methylene Blue-Raloxifene Conjugates for Efficient Breast Tumor Elimination Triggered by ERα Degradation. J Med Chem. 2025 Apr 24;68(8):8861-8872. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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ERα degrader 13

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ERα degrader 13 Related Classifications

HY-172937 Related Classifications