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SAMD11 - sterile alpha motif domain containing 11 Gene

Also Known as MRS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 148398

About SAMD11

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:923,923-944,574 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 7.4), endometrium (RPKM 5.9) and 25 other tissues.

Summary

Predicted to enable several functions, including histone binding activity; protein domain specific binding activity; and protein self-association. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SAMD11 Products (3)

mRNA	Protein	Name
NM_001385640.1	NP_001372569.1	sterile alpha motif domain-containing protein 11 isoform 2
NM_001385641.1	NP_001372570.1	sterile alpha motif domain-containing protein 11 isoform 1
NM_152486.4	NP_689699.3	sterile alpha motif domain-containing protein 11 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAMD11 Protein Structure

SAM_2

0
200
400
600
681 a.a.

Protein Preferred Names	Protein Names
sterile alpha motif domain-containing protein 11	SAM domain-containing protein 11

SAMD11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	SAMD11	Q96NU1	RTL8C	Homo sapiens	A6ZKI3	Y2H Array	32296183
Intra	SAMD11	Q96NU1	RTL8C	Homo sapiens	A6ZKI3	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	SAMD11	Q96NU1	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	SAMD11	Q96NU1	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	SAMD11	Q96NU1	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	SAMD11	Q96NU1	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	SAMD11	Q96NU1	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	SAMD11	Q96NU1	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	SAMD11	Q96NU1	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	SAMD11	Q96NU1	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	SAMD11	Q96NU1	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	SAMD11	Q96NU1	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	SAMD11	Q96NU1	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	SAMD11	Q96NU1	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	SAMD11	Q96NU1	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	SAMD11	Q96NU1	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	SAMD11	Q96NU1	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	CT55	Homo sapiens	Q8WUE5	Y2H Array	32296183
Intra	SAMD11	Q96NU1	CT55	Homo sapiens	Q8WUE5	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	SAMD11	Q96NU1	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	SAMD11	Q96NU1	JMJD7	Homo sapiens	P0C870	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	JMJD7	Homo sapiens	P0C870	Y2H Array	32296183
Intra	SAMD11	Q96NU1	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
Intra	SAMD11	Q96NU1	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SAMD11	Q96NU1	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	SAMD11	Q96NU1	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	SAMD11	Q96NU1	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Intestinal Vascular Insufficiency	Chronic Mesenteric Ischemia Cmi - Chronic Mesenteric Ischaemia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS12423	SAMD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SAMD11	VGNC	VGNC:45849
Bos taurus	SAMD11	VGNC	VGNC:59361
Felis catus	SAMD11	VGNC	VGNC:64861
Rattus norvegicus	SAMD11	RGD	RGD:1310271
Mus musculus	SAMD11	MGD	MGI:2446220
Others	SAMD11	NCBI