2. Disease Areas
  3. Inflammation or Immune System Disease Respiratory Disease Digestive System Disease
  4. Pulmonary Disease Chronic Disease and Inflammation Respiratory Inflammation Autoimmune Disease Peptic Ulcer Disease
  5. Chronic Obstructive Pulmonary Disease Ulcerative Colitis
  6. Etamiphyllin camsylate

Etamiphyllin camsylate  (Synonyms: Etamiphylline camsylate)

Cat. No.: HY-105762A
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Etamiphyllin (Etamiphylline) camsylate is a respiratory and cardiac stimulant. Etamiphyllin camsylate relaxes bronchial and bronchiolar smooth muscle to open airways, and increases cardiac output without elevating heart rate. The level of Etamiphyllin camsylate decreases in mice with ulcerative colitis, and it is positively correlated with *Bifidobacterium* and *Faecalibacterium*. Etamiphyllin camsylate can be applied to research related to chronic obstructive pulmonary disease, respiratory failure and ulcerative colitis.

For research use only. We do not sell to patients.

Etamiphyllin camsylate

Etamiphyllin camsylate Chemical Structure

CAS No. : 19326-29-5

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Description

Etamiphyllin (Etamiphylline) camsylate is a respiratory and cardiac stimulant. Etamiphyllin camsylate relaxes bronchial and bronchiolar smooth muscle to open airways, and increases cardiac output without elevating heart rate. The level of Etamiphyllin camsylate decreases in mice with ulcerative colitis, and it is positively correlated with *Bifidobacterium* and *Faecalibacterium*. Etamiphyllin camsylate can be applied to research related to chronic obstructive pulmonary disease, respiratory failure and ulcerative colitis[1][2].

In Vivo

Etamiphyllin (camsylate) (2.8 mg/kg; i.v.; single dose) administered intravenously to healthy male Thoroughbred horses results in detection of the parent drug and three metabolites in plasma and urine up to 32 hours post-administration, with N-desethyletamiphylline as the primary metabolite and N-desethyl-N-desmethyletamiphylline detected only in urine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thoroughbred (male, ages 6 and 16, body weights 498 and 537 kg)[2]
Dosage: 2.8 mg/kg
Administration: i.v.; single dose
Result: Detected in plasma and urine samples, with a characteristic m/z 207 fragment ion from loss of N,N-diethylamine.
Detected the main metabolite, N-desethyletamiphylline (molecular weight 251), in plasma and urine up to 32 hours post-administration, with a protonated molecular ion ([M+H]+) at m/z 252.1455 and product ions at m/z 207.0879 and m/z 163.0979.
Detected two isomers of N1/N3-desmethyletamiphylline (molecular weight 265) as minor metabolites in plasma and urine, with [M+H]+ ions at m/z 266.1613 and m/z 266.1615, and common product ion m/z 193.0721/193.0723 from loss of N,N-diethylamine.
Detected N-desethyl-N-desmethyletamiphylline (molecular weight 238) as a minor metabolite in urine, with [M+H]+ ion at m/z 238.1300 and product ion m/z 193.0722 from loss of N-ethylamine.
Molecular Weight

511.63

Formula

C23H37N5O6S
CAS No.
SMILES

CCN(CC)CCN1C2=C(N(C(N(C)C2=O)=O)C)N=C1.O=S(C[C@@]3(C4(C)C)C(C[C@@]4([H])CC3)=O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Etamiphyllin camsylate Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etamiphyllin19326-29-5EtamiphyllineOthersbronchial smooth musclebronchiolar smooth muscledextran sulfate sodium-induced ulcerative colitis micerespiratory failureBifidobacteriumulcerative colitisFaecalibaculumdesethyletamiphyllinechronic obstructive pulmonary diseasehorsesInhibitorinhibitorinhibit

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