Fenspiride-d5 hydrochloride
Fenspiride-d5 hydrochloride is the deuterium labeled Fenspiride hydrochloride (HY-A0027). Fenspiride hydrochloride is an α adrenergic and H1 histamine receptor antagonist.
For research use only. We do not sell to patients.
- CAS No.: 1246815-28-0
- Formula: C15H16D5ClN2O2
- Molecular Weight:301.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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H1 Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246815-28-0
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Unlabeled Cas 5053-08-7
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Molecular Weight 301.82
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Formula C15H16D5ClN2O2
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SMILES
O=C1OC2(CN1)CCN(CC2)CCC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H].Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Lebedenko AA, Mal'tsev SV. .[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.] Vestn Otorinolaringol. 2011;(4):66-67. [Content Brief]
[3]. Khawaja AM, Liu YC, Rogers DF. et al.Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther. 1999;12(6):363-8. [Content Brief]
[4]. Zielnik-Jurkiewicz B, Jurkiewicz D. et al. Usefulness of fenspiride in the treatment of acute otitis media in children. Pol Merkur Lekarski. 2005 Jun;18(108):624-8. [Content Brief]
[5]. Bee D, Laude EA, Emery CJ, Howard P. Effect of fenspiride on pulmonary function in the rat and guinea pig. Clin Sci (Lond). 1995 Mar;88(3):325-30. [Content Brief]
[6]. Fenspiride
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fenspiride-d5 hydrochloride Related Classifications
HY-A0027S Related Classifications
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