FNT12

FNT12 (24 h) exhibits potent narrow-spectrum activity against Pseudomonas aeruginosa with an MIC of 5.00 μg/mL, while showing almost no inhibitory activity against Enterococcus faecalis, Streptococcus mutans, and Escherichia coli^[1].
FNT12 (MIC value; 24 h) exhibits potent antibiofilm activity, disrupting up to 44.32% of preformed Pseudomonas aeruginosa biofilms^[1].
FNT12 (30 min) exhibits moderate antioxidant activity in DPPH radical scavenging assays and ABTS radical scavenging assays^[1].
FNT12 (computational molecular docking and 50 ns molecular dynamics simulation) stably binds to the pocket of the Pseudomonas aeruginosa quorum-sensing protein LasR; MM-GBSA predicts a binding free energy of -14.47 kcal/mol, and the complex stability is maintained by extensive π-π stacking, π-alkyl, and carbon-hydrogen bond hydrophobic interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.