2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. FSHR agonist 1

FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR.

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FSHR agonist 1

FSHR agonist 1 Estructura química

No. CAS : 1256776-89-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

FSHR agonist 1 Related Antibodies

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Descripciòn

FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR[1].

IC50 & Target

pEC50: 7.72 (FSHR)[1]
In Vitro

The binding of FSHR agonist 1 (compound 21f) to the FSHR TMD pocket induces inward movements of TM6 and TM7, which directly results in FSHR activation[1].
FSHR agonist 1 (compound 21f) can activate FSHR, LHCGR and TSHR with highly potency and efficacy, while the activation potency for FSHR is more than 10-fold higher than LHCGR (pEC50 of 6.26) and TSHR (pEC50 of 6.48)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FSHR agonist 1 Related Antibodies
Peso molecular

467.62

Fòrmula

C26H33N3O3S
No. CAS
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N(C(C)(C)C)CC)C1=NC(C2=CC=CS2)=C3C4=C(CCN13)C=C(OC)C(OC(C)C)=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (106.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1385 mL 10.6924 mL 21.3849 mL
5 mM 0.4277 mL 2.1385 mL 4.2770 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
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Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1385 mL 10.6924 mL 21.3849 mL 53.4622 mL
5 mM 0.4277 mL 2.1385 mL 4.2770 mL 10.6924 mL
10 mM 0.2138 mL 1.0692 mL 2.1385 mL 5.3462 mL
15 mM 0.1426 mL 0.7128 mL 1.4257 mL 3.5641 mL
20 mM 0.1069 mL 0.5346 mL 1.0692 mL 2.6731 mL
25 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1385 mL
30 mM 0.0713 mL 0.3564 mL 0.7128 mL 1.7821 mL
40 mM 0.0535 mL 0.2673 mL 0.5346 mL 1.3366 mL
50 mM 0.0428 mL 0.2138 mL 0.4277 mL 1.0692 mL
60 mM 0.0356 mL 0.1782 mL 0.3564 mL 0.8910 mL
80 mM 0.0267 mL 0.1337 mL 0.2673 mL 0.6683 mL
100 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5346 mL
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FSHR agonist 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSHR agonist 11256776-89-2FSHR agonist1FSHR agonist-1Estrogen Receptor/ERRallostericFSHRTMDLHCGRTSHRInhibitorinhibitorinhibit

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Nombre del producto:
FSHR agonist 1
Cat. No.:
HY-150210
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