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Cat. No.: HY-182029

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G-quadruplex ligand 5

G-quadruplex ligand 5 is a G-quadruplex (G4) ligand. G-quadruplex ligand 5 selectively stabilizes cancer-associated G4 oligonucleotides and shows cytotoxicity toward cancer cells. G-quadruplex ligand 5 can be used for the research of cancer.

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Formule: C₂₉H₃₀I₂N₄O₂S₂
Masse moléculaire:784.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

G-quadruplex ligand 5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
Bioz

Activité biologique

Description

In Vitro

G-quadruplex ligand 5 (Compound 2o) (10 μM) selectively stabilizes cancer-associated G4 oligonucleotides by up to 5°C, with no stabilization of duplex DNA^[1].
G-quadruplex ligand 5 (10 μM) binds the c-Myc G4 sequence with a K_a of 1.7 ± 0.1 μM^-1^[1].
G-quadruplex ligand 5 binds to groove and loop regions of antiparallel telo22, parallel c-Myc, and hybrid telo23 G4s, inducing widespread spectral perturbations^[1].
G-quadruplex ligand 5 (1-100 μM; 72 h) exhibits selective cytotoxicity toward HeLa cancer cells with an IC₅₀ of 7.8 ± 0.4 μM after incubation in the dark, with no appreciable toxicity in healthy HDF cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cervical cancer cells, healthy human dermal fibroblasts (HDF)
Concentration:

1-100 μM
Incubation Time:

72 h (dark incubation)
Result:

Exhibited an IC₅₀ of 7.8 ± 0.4 μM in HeLa cells.
Showed negligible cytotoxicity in HDF cells (IC₅₀ > 100 μM).

Related Protocols :

Chemical Information

Masse moléculaire 784.51
Formule C₂₉H₃₀I₂N₄O₂S₂
SMILES

CC1=C(C=C(S1)C(NC2=CC=[N+](C=C2)C)=O)C3=C(CCC3)C4=C(SC(C(NC5=CC=[N+](C=C5)C)=O)=C4)C.[I-].[I-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Allen NM, et al. Red-light-activated and thermally-stable amido-dithienylethenes for the reversible control of G-quadruplex binding and anticancer activity. Bioorg Chem. Published online March 2, 2026. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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