country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182029

Copy Link Print Information

G-quadruplex ligand 5

G-quadruplex ligand 5 is a G-quadruplex (G4) ligand. G-quadruplex ligand 5 selectively stabilizes cancer-associated G4 oligonucleotides and shows cytotoxicity toward cancer cells. G-quadruplex ligand 5 can be used for the research of cancer.

For research use only. We do not sell to patients.

Formula: C₂₉H₃₀I₂N₄O₂S₂
Molecular Weight:784.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

G-quadruplex ligand 5 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

G-quadruplex ligand 5 (Compound 2o) (10 μM) selectively stabilizes cancer-associated G4 oligonucleotides by up to 5°C, with no stabilization of duplex DNA^[1].
G-quadruplex ligand 5 (10 μM) binds the c-Myc G4 sequence with a K_a of 1.7 ± 0.1 μM^-1^[1].
G-quadruplex ligand 5 binds to groove and loop regions of antiparallel telo22, parallel c-Myc, and hybrid telo23 G4s, inducing widespread spectral perturbations^[1].
G-quadruplex ligand 5 (1-100 μM; 72 h) exhibits selective cytotoxicity toward HeLa cancer cells with an IC₅₀ of 7.8 ± 0.4 μM after incubation in the dark, with no appreciable toxicity in healthy HDF cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cervical cancer cells, healthy human dermal fibroblasts (HDF)
Concentration:

1-100 μM
Incubation Time:

72 h (dark incubation)
Result:

Exhibited an IC₅₀ of 7.8 ± 0.4 μM in HeLa cells.
Showed negligible cytotoxicity in HDF cells (IC₅₀ > 100 μM).

Chemical Information

Molecular Weight 784.51
Formula C₂₉H₃₀I₂N₄O₂S₂
SMILES

CC1=C(C=C(S1)C(NC2=CC=[N+](C=C2)C)=O)C3=C(CCC3)C4=C(SC(C(NC5=CC=[N+](C=C5)C)=O)=C4)C.[I-].[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Allen NM, et al. Red-light-activated and thermally-stable amido-dithienylethenes for the reversible control of G-quadruplex binding and anticancer activity. Bioorg Chem. Published online March 2, 2026. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote