G-quadruplex ligand 5 

G-quadruplex ligand 5 is a G-quadruplex (G4) ligand. G-quadruplex ligand 5 selectively stabilizes cancer-associated G4 oligonucleotides and shows cytotoxicity toward cancer cells. G-quadruplex ligand 5 can be used for the research of cancer^[1].

G-quadruplex ligand 5 (Compound 2o) (10 μM) selectively stabilizes cancer-associated G4 oligonucleotides by up to 5°C, with no stabilization of duplex DNA^[1].
G-quadruplex ligand 5 (10 μM) binds the c-Myc G4 sequence with a K_a of 1.7 ± 0.1 μM^-1[1].
G-quadruplex ligand 5 binds to groove and loop regions of antiparallel telo22, parallel c-Myc, and hybrid telo23 G4s, inducing widespread spectral perturbations^[1].
G-quadruplex ligand 5 (1-100 μM; 72 h) exhibits selective cytotoxicity toward HeLa cancer cells with an IC₅₀ of 7.8 ± 0.4 μM after incubation in the dark, with no appreciable toxicity in healthy HDF cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

784.51

C₂₉H₃₀I₂N₄O₂S₂

CC1=C(C=C(S1)C(NC2=CC=[N+](C=C2)C)=O)C3=C(CCC3)C4=C(SC(C(NC5=CC=[N+](C=C5)C)=O)=C4)C.[I-].[I-]

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• [1]. Allen NM, et al. Red-light-activated and thermally-stable amido-dithienylethenes for the reversible control of G-quadruplex binding and anticancer activity. Bioorg Chem. Published online March 2, 2026.  [Content Brief]