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Referencia número: HY-13320

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2-Keto Crizotinib

Name: 2-Keto Crizotinib
Brand: MedChemExpress
SKU: HY-13320
Price: 668.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PF-06260182)

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1415558-82-5
Fòrmula: C₂₁H₂₀Cl₂FN₅O₂
Peso molecular:464.32

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

2-Keto Crizotinib Chemical Structure

No. CAS: 1415558-82-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Publications (1)
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Actividad biológica

Descripciòn

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

In Vitro

2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1415558-82-5
Peso molecular 464.32
Fòrmula C₂₁H₂₀Cl₂FN₅O₂
SMILES

O=C1CC(N2N=CC(C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=C3)=C2)CCN1
Synonyms

PF-06260182
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Gene

Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway. [Abstract]

2022 Jul 20;832:146559. PMID: 35569765

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181- [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

2-Keto Crizotinib

1 Cited Publications

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Actividad biológica
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- In Vitro
Chemical Information
Publications (1)
Pureza y Documentación
Referencias

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2-Keto Crizotinib

Publications Citing Use of MedChemExpress (MCE) 2-Keto Crizotinib