ASM-IN-3
ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats.
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- No. CAS: 2342576-75-2
- Fòrmula: C17H13ClN2O4
- Peso molecular:344.75
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
161 μM
Compound: 21b
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Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 31944697] |
In Vitro
In Vivo
ASM-IN-3 (6-24 mg/kg, i.p., twice a day for 2 weeks) shows favorable antidepressant-like effects by decreasing brain ASM activity and restoring neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Reserpine-induced depressed SD rats (6−8 weeks, 200 g, female, were injected intraperitoneally with Reserpine (4 mg/kg) daily)[1]
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Dosage:6, 12, 24 mg/kg
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Administration:Intraperitoneal injection (i.p.), twice a day for 2 weeks
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Result:Improved sugar consumption in a dose dependent manner after 2 days of tap water drinking and following 20 h of water depletion and fasting.
Decreased the total time in center of rats, and increased times passing the grid and frequency of grooming in the open-field test.
Demonstrated a reduction of the cortical and hippocampal ASM activity by approximately 27% and 33%, respectively, compared to the model group at a dose of 24 mg/kg.
Prevented the inhibitory effect of Reserpine on neurogenesis and restored neurogenesis.
Chemical Information
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No. CAS 2342576-75-2
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Peso molecular 344.75
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Fòrmula C17H13ClN2O4
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SMILES
O=C(C1=CC(OCC2=CC=C(C3=CC=C(Cl)C=C3)C=C2)=NO1)NO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASM-IN-3 Related Classifications
HY-171033 Related Classifications
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