BW-AQ-113
BW-AQ-113 is an Anthraquinone (HY-N0354) derivative. BW-AQ-113 can specifically degrade MDM2 and activate the p53 pathway. BW-AQ-113 can induce apoptosis by downregulating anti-apoptotic gene Bcl-2 and regulating pro-apoptotic gene Bax and CASP3. BW-AQ-113 can be used for research of p53 wild-type hematological malignancies.
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- No. CAS: 1537900-10-9
- Fòrmula: C20H18ClNO5
- Peso molecular:387.81
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Actividad biológica
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Bcl-2 |
Bax |
Caspase 3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
2.1 μM
Compound: BW-AQ-113
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Cytotoxicity against p53 repressed human HeLa cells asessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against p53 repressed human HeLa cells asessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 31324563] |
BW-AQ-113 shows IC50 values of 0.12 and 0.2 μM against Molt-4 and EU-1 cells[1].
BW-AQ-113 shows IC50 values of 0.74, 5.2 and 2.1 μM against K562 cells with p53 deficiency, T98G cells with p53 mutation and HeLa cells with p53 suppression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1537900-10-9
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Peso molecular 387.81
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Fòrmula C20H18ClNO5
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SMILES
ClCC(NC1=CC(OCC)=C(C(C2=C3C=CC=C2OCC)=O)C(C3=O)=C1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BW-AQ-113 Related Classifications
HY-177208 Related Classifications
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