CDK5-IN-4
CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research.
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- No. CAS: 1212711-91-5
- Fòrmula: C24H24FN5O3
- Peso molecular:449.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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GSK-3α 0.98 ± 0.0 μM (IC50) |
GSK-3β 4.00 ± 1.3 μM (IC50) |
CDK9 1.76 ± 0.3 μM (IC50) |
CDK2 6.24 ± 2.8 μM (IC50) |
CDK5 9.8 ± 2.29 μM (IC50) |
Chemical Information
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No. CAS 1212711-91-5
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Peso molecular 449.48
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Fòrmula C24H24FN5O3
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SMILES
O=C(N[C@H]1CO[C@@H]2[C@H](CO[C@H]12)NC3=NC(C4=CC=CC(F)=C4)=CC=N3)NCC5=CC=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK5-IN-4 Related Classifications
HY-161595 Related Classifications
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