FAAH-IN-7
FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model.
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- No. CAS: 3037600-36-2
- Fòrmula: C26H29N3O4
- Peso molecular:447.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
6.4 μM
Compound: 4e
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Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay
Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay
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[PMID: 36462439] |
In Vitro
FAAH-IN-7 (compound 4e) (10 nM-30 μM; 24 h) has no cytotoxicity against mouse fibroblasts NIH3T3 and human astrocytes cell line 1321N1 with Ki values >10 μM[1].
FAAH-IN-7 (10 nM, 100 nM; 30 min) inhibits FAAH through a reversible mechanism in the case of rapid dilution. The rapid dilution disrupts the equilibrium between the inhibitor and the enzyme, resulting in enzymatic activity recovery[1].
FAAH-IN-7 (1 nM-1 μM; 24 h) significantly reduces ROS production starting from the 10 nM concentration in 1321N1 astrocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:1321N1 human astrocytes
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Concentration:10 nM, 100 nM, 1 μM, 10 μM, and 30 μM
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Incubation Time:24 hours
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Result:Showed no cytotoxicity against 1321N1 human astrocytes.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3037600-36-2
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Peso molecular 447.53
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Fòrmula C26H29N3O4
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SMILES
O=C(N1CCN(CCCC2=CC=CC=C2)CC1)OC3=CC=CC(C4=C(C(N)=O)C=C(C)O4)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAAH-IN-7 Related Classifications
HY-151919 Related Classifications
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