GRIK3 - glutamate ionotropic receptor kainate type subunit 3 Gene

Also Known as EAA5; GLR7; GLUR7; GluK3; GluR7a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2899

About GRIK3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,795,527-37,034,515 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 17 paralogues. Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues.

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the Other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

GRIK3 Products (1)

mRNA	Protein	Name
NM_000831.4	NP_000822.2	glutamate receptor ionotropic, kainate 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IDA IDA: Inferred from direct assay	9144652	GOA
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	11124978	GOA
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	7719709	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in G protein-coupled glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	9144652	GOA
involved in glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	7719709	GOA
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	11124978	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	7719709	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIK3 Protein Structure

ANF_receptor

Lig_chan-Glu_bd

Lig_chan

0
200
400
600
800
919 a.a.

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, kainate 3	dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))

GRIK3 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P84525	GRIK3 Antibody (YA4222)	ICC/IF, ELISA	Human
HY-P84525A	GRIK3 Antibody (YA4222)(PBS only)	ICC/IF, ELISA	Human
HY-P84526	GRIK3 Antibody (YA4223)	WB, FC, ELISA	Human
HY-P84526A	GRIK3 Antibody (YA4223)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Depersonalization Disorder	Neurotic Derealization Depersonalization Depersonalization/Derealization Disorder Depersonalisation-Derealization Syndrome Depersonalisation Disorder Depersonalisation Neurosis Depersonalisation Syndrome Feeling Of Unreality Feels Own Self Is Unreal Neurotic State With Depersonalisation Neurotic State With Depersonalization Episode
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Neuronitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS05800	GRIK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20947	Grik3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27464	Grik3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GRIK3	VGNC	VGNC:41488
Macaca mulatta	GRIK3	VGNC	VGNC:73278
Bos taurus	GRIK3	VGNC	VGNC:29644
Mus musculus	GRIK3	MGD	MGI:95816
Felis catus	GRIK3	VGNC	VGNC:67469
Rattus norvegicus	GRIK3	RGD	RGD:71027
Others	GRIK3	NCBI