KF-19418
KF-19418 is a hair follicle stimulator with hair growth promoting activity. KF-19418 stimulates proliferation of cultured hair bulb cells from newborn mice. KF-19418 accelerates hair regrowth in hair-clipped mouse alopecia model following topical application. KF-19418 can be used for the research of alopecia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 147508-06-3
- Fòrmula: C21H14N4O
- Peso molecular:338.36
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
KF-19418 (0.001-10 μM; 4 days) concentration-dependently stimulates proliferation of hair bulb cells isolated from 4-day-old C3H/HeN mice, reaching ~240% of control growth at 10 μM over 4 days, while maintaining immature cell morphology and melanocyte populations[1].
KF-19418 (3-10 μM; 3 days) promotes hair follicle elongation in cultured whole skin pieces from 4-week-old C3H mice in anagen phase, with 10 μM increasing tissue area by ~13% over 3 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C3H mice (8-week-old, telogen phase)[1]
-
Dosage:1% suspension
-
Administration:topical; daily; 2 weeks
-
Result:Reached a hair-regrown area to shaved area ratio of 38.4%.
Showed visible hair regrowth after 1 week of application.
Caused no visible skin abnormalities (e.g., inflammation).
Chemical Information
-
No. CAS 147508-06-3
-
Peso molecular 338.36
-
Fòrmula C21H14N4O
-
SMILES
O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NN=C2C5=CC=CC=C5
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KF-19418 Related Classifications
HY-167655 Related Classifications
Powered by Bioz