N2W2
N2W2 is a tryptophan- and lysine-rich β-hairpin antimicrobial peptide. N2W2 exhibits potent antimicrobial activity but also high toxicity. N2W2 is highly susceptible to trypsin or chymotrypsin. N2W2 can be used for the research of bacterial infection.
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- Fòrmula: C90H111N21O10
- Peso molecular:1646.98
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
N2W2 (2-256 μM; 18 h) exhibits potent antimicrobial activity against S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, K. pneumoniae ATCC 700603, E. coli ATCC 25922, and P. aeruginosa ATCC 27853 with a geometric mean of the MIC of 6.3 μM[1].
N2W2 (16-2048 μM; 1 h) exhibits high hemolytic activity against Kunming mouse blood cells with an MHC of 70.8 μM[1].
N2W2 (1 h) exhibits significant cytotoxicity against NRK-52E and GES-1 cells with CC50 values of 10.1 μM and 4.3 μM, respectively[1].
N2W2 is highly susceptible to trypsin or
chymotrypsin and nearly lost their antimicrobial activity after incubation with trypsin or chymotrypsin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Peso molecular 1646.98
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Fòrmula C90H111N21O10
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Sequence
Trp-Lys-Trp-Lys-Trp-Trp-Lys-Trp-Lys-Trp-NH2
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Sequence Shortening
WKWKWWKWKW-NH2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N2W2 Related Classifications
HY-P11583 Related Classifications
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