Copy Link Print Information

Patritumab

(Synonyms: AMG-888; U3-1287)
2 Cited Publications
Revisión del cliente

Based on 2 publication(s) in Google Scholar

Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.28%
  • No. CAS: 1262787-83-6
  • Peso molecular:146.86 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Experimental Validation Results for Patritumab
  • Patritumab Chemical Structure
    Patritumab Chemical Structure
No. CAS: 1262787-83-6
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Patritumab

More
Customer Validation & Images
WB
  • WB

Ver todos los productos específicos de isoformas EGFR

More

Ver todos los productos específicos de isoformas Akt

More

Ver todos los productos específicos de isoformas ERK

More

Ver todos los productos específicos de isoformas PARP

More
Keywords
100 mg

Obtener un presupuesto En stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1×106 MCF-7 cells labelling HER3 (red) with Patritumab (HY-P99275). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1(K214R) kappa Isotype Control (HY-P99995, blue) was used as the isotype control.

  • 1/16

    Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Patritumab. The EC50 for this effect is 1.41 ng/mL.

  • 1/16

    Loaded Patritumab on AHC2 biosensor, can bind HER3 Protein, Human (HEK293, His, HY-P72625) with an affinity constant of 1.804E-09 M as determined in BLI assay.

  • 1/16

    Patritumab purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2024 Apr 15;30(8):1530-1543. [Abstract]

    Customer Validation
     Patritumab (10 μM; 2 h) reduced pHER3 after NRG1 stimulation (100 ng/mL; 15 min) in CWR-R1 cells.

  • Patritumab Chemical Structure
    1/16
  • Patritumab
  • Flow cytometric analysis of 1×106 MCF-7 cells labelling HER3 (red) with Patritumab (HY-P99275). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1(K214R) kappa Isotype Control (HY-P99995, blue) was used as the isotype control.
  • Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Patritumab. The EC50 for this effect is 1.41 ng/mL.
  • Loaded Patritumab on AHC2 biosensor, can bind HER3 Protein, Human (HEK293, His, HY-P72625) with an affinity constant of 1.804E-09 M as determined in BLI assay.