Thalidomide-benzo
Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs.
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- No. CAS: 458151-34-3
- Fòrmula: C17H12N2O4
- Peso molecular:308.29
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against human DLD1 cells by MTT assay
Cytotoxicity against human DLD1 cells by MTT assay
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[PMID: 19394719] |
| HL-60 | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
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[PMID: 19394719] |
| HT-29 | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against human HT-29 cells by MTT assay
Cytotoxicity against human HT-29 cells by MTT assay
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[PMID: 19394719] |
| HUVEC | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against HUVEC by MTT assay
Cytotoxicity against HUVEC by MTT assay
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[PMID: 19394719] |
| ST486 | IC50 |
>50 μM
Compound: 1d
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Cytotoxicity against human ST486 cells by MTT assay
Cytotoxicity against human ST486 cells by MTT assay
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[PMID: 19394719] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 458151-34-3
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Peso molecular 308.29
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Fòrmula C17H12N2O4
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SMILES
O=C1NC(C(CC1)N2C(C3=CC4=C(C=C3C2=O)C=CC=C4)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thalidomide-benzo Related Classifications
HY-139549 Related Classifications
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