1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. GBR 12783 dihydrochloride

GBR 12783 dihydrochloride 

Cat. No.: HY-100968
Handling Instructions

GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

For research use only. We do not sell to patients.

GBR 12783 dihydrochloride Chemical Structure

GBR 12783 dihydrochloride Chemical Structure

CAS No. : 67469-75-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 160 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2].

In Vivo

GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].

Animal Model: Male Sprague-Dawley rats (180-200 g)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; for 100 minutes
Result: For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
Molecular Weight

485.49

Formula

C₂₈H₃₄Cl₂N₂O

CAS No.

67469-75-4

SMILES

N1(CCOC(C2=CC=CC=C2)C3=CC=CC=C3)CCN(C/C=C/C4=CC=CC=C4)CC1.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GBR 12783GBR12783GBR-12783Dopamine ReceptorInhibitorinhibitorinhibit

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GBR 12783 dihydrochloride
Cat. No.:
HY-100968
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