The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release

  • Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5. doi: 10.1016/s0926-6410(98)00023-8.
K Nail-Boucherie  1 ,  N Dourmap ,  R Jaffard ,  J Costentin
Affiliations
  • 1. Unité de Neuropsychopharmacologie expérimentale, E.S.A 6036 C.N.R. S., I.F.R.M.P. no. 23, Faculté de Médecine et de Pharmacie de Rouen, avenue de l'Université, F-76803, Saint-Etienne-du-Rouvray, France.
PMID: 9774732 DOI: 10.1016/s0926-6410(98)00023-8
Abstract

The specific dopamine uptake inhibitor, GBR 12783 was tested on the retention performance of a one-trial passive avoidance test. For a moderate electric shock intensity, GBR 12783 (10 mg/kg), injected before acquisition session, improved retention performance. Scopolamine (0.125-0.5 mg/kg) completely blocked the promnesic effect of GBR 12783. Moreover, GBR 12783 increased hippocampal acetylcholine release in vivo. These data suggest that the promnesic effect of GBR 12783 is mediated by an increase in the septo-hippocampal cholinergic transmission.

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