CLEC4M - C-type lectin domain family 4 member M Gene

Also Known as CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10332

About CLEC4M

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,763,243-7,769,605 (from NCBI)

This gene has 7 transcripts (splice variants), 924 orthologues and 14 paralogues. Biased expression in liver (RPKM 15.4), lymph node (RPKM 9.8) and 3 other tissues.

Summary

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS Infection. [provided by RefSeq, May 2020]

CLEC4M Products (9)

mRNA Protein Name
NM_001144904.2 NP_001138376.1 C-type lectin domain family 4 member M isoform 2
NM_001144905.2 NP_001138377.1 C-type lectin domain family 4 member M isoform 12
NM_001144906.2 NP_001138378.1 C-type lectin domain family 4 member M isoform 7
NM_001144907.2 NP_001138379.1 C-type lectin domain family 4 member M isoform 11
NM_001144908.2 NP_001138380.1 C-type lectin domain family 4 member M isoform 10
NM_001144909.2 NP_001138381.1 C-type lectin domain family 4 member M isoform 9
NM_001144910.2 NP_001138382.1 C-type lectin domain family 4 member M isoform 8
NM_001144911.2 NP_001138383.1 C-type lectin domain family 4 member M isoform 3
NM_014257.5 NP_055072.3 C-type lectin domain family 4 member M isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
12609975 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables virus receptor activity IDA
IDA: Inferred from direct assay
15496474 GOA
enables virus receptor activity IMP
IMP: Inferred from mutant phenotype
15496474 GOA
Biological Process GO Annotation Evidence References Source
involved in receptor-mediated virion attachment to host cell IDA
IDA: Inferred from direct assay
15479853 GOA
involved in symbiont entry into host cell IDA
IDA: Inferred from direct assay
15479853 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC4M Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (286 - 391)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member M

  • CD209 antigen-like protein 1

CLEC4M Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
CLEC4M Q9H2X3 S SARS-CoV-2 P0DTC2
Anti Tag CoIP
34341769
Intra
CLEC4M Q9H2X3 GRN Homo sapiens P28799
Anti Tag CoIP
33961781
Intra
CLEC4M Q9H2X3 ACE2 Homo sapiens Q9BYF1
Pull Down
34341769
Intra
CLEC4M Q9H2X3 ACE2 Homo sapiens Q9BYF1
Anti Tag CoIP
34341769
Intra
CLEC4M Q9H2X3 ACE2 Homo sapiens Q9BYF1
Anti Bait CoIP
34341769
Intra
CLEC4M Q9H2X3 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
Intra
CLEC4M Q9H2X3 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC4M Proteins

Cat. No. Product Name Accession Purity
HY-P72739 CD299 Protein, Human (HEK293, His-Flag) Q9H2X3-8 (S73-E376) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76219 CD299 Protein, Human (HEK293, hFc, solution) Q9H2X3-1/NP_055072.3 (S78-E399) ≥ 90%, as determined by reducing SDS-PAGE.

CLEC4M Antibodies

Cat. No. Product Name Application Reactivity
HY-P84794 CD299 Antibody (YA4491) WB, FC, ELISA Human
HY-P84794A CD299 Antibody (YA4491)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
West Nile Virus

  • West Nile Virus, Susceptibility To

  • Wnv

  • Wnv, Susceptibility To

  • West Nile Viral Infection

  • Encephalitis, West Nile Fever

  • West Nile Fever
Japanese Encephalitis

  • Japanese B Encephalitis

  • Je

  • Encephalitis Japanese

  • Encephalitis, Japanese

  • Russian Autumnal Encephalitis

  • Je - [Japanese Encephalitis]

  • Japanese Encephalitis Virus Disease

  • Jbe - [Japanese B Encephalitis}

  • B Type Encephalitis
Hepatitis C

  • Chronic Hepatitis C

  • Hepatitis C Infection

  • Hepatitis Nona Nonb

  • Nanbh

  • Viral Hepatitis C

  • Hepatitis C Chronic

  • Hepatitis C, Chronic

  • Chronic Type C Viral Hepatitis

  • Chronic Hcv - [Hepatitis C Virus] Infection

  • Hepatitis C Nos

  • Hepatitis C Infection Nos

  • Hepatitis C-Related Cirrhosis

  • Type C Viral Hepatitis

  • Hep C Nos
Encephalitis

  • Mumps Encephalitis

  • Mumps Meningoencephalitis

  • Herpes Simplex Neuroinvasion

  • Herpetic Encephalitis

  • Herpetic Encephalopathy

  • Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

  • Encephalitis Due To Herpesviridae

  • Encephalitis Due To Herpesvirus

  • Herpes Encephalitis

  • Herpesviral Encephalitis

  • Herpes Simplex Encephalitis

  • Hsv - [Herpes Simplex Virus] Encephalitis

  • Herpes Virus Encephalitis

  • Simian B Disease

  • Simian B Disorder

  • Encephalitis Nec

  • Idiopathic Encephalitis
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Hepatitis C Virus

  • Hepatitis C Virus, Susceptibility To

  • Hepatitis C Virus Infection, Response To Therapy Of

  • Hcv

  • Hcv, Susceptibility To

  • Hepatitis C Virus, Resistance To

  • Hepatitis C Virus, Response To Therapy Of

  • Resistance To Hepatitis C Virus
Severe Acute Respiratory Syndrome

  • Sars

  • Sars-Cov Infection

  • Sars-1

  • Sar Deficiency

  • Sars - [Severe Acute Respiratory Syndrome]
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Marburg Hemorrhagic Fever

  • Marburg Virus Disease

  • Marburg Disease

  • Green Monkey Disease

  • Mhf

  • Vervet Monkey Disease

  • Mard - [Marburg Disease]

  • Mvd - [Marburg Virus Disease]

  • Marburg Haemorrhagic Fever

  • Mhf - [Marburg Haemorrhagic Fever]
Disease By Infectious Agent

  • Infectious Disease

  • Infectious Diseases
Von Willebrand Disease, Type 1

  • Von Willebrand Disease Type 1

  • VWD1

  • Von Willebrand'S Disease 1

  • Von Willebrand Disease Type I

  • Von Willebrand Disease, Type I

  • Vwd, Type 1

  • Vwd Type 1

  • Von Willebrand Disease 1

  • Von Willebrand Factor Deficiency Type 1

  • Von Willebrand Disease, Type 1, Susceptibility To
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Ebola Hemorrhagic Fever

  • Ebola Virus Disease

  • Viral Hemorrhagic Fever

  • Hemorrhagic Fever, Ebola

  • Ebola

  • Ehf

  • Ebola Fever

  • Hemorrhagic Fevers, Viral

  • Ebola Haemorrhagic Fever

  • Ebod - [Ebola Disease]

  • Evd - [Ebola Virus Disease]

  • Ebola Virus Haemorrhagic Fever

  • Vhf - [Viral Haemorrhagic Fever] Nos

  • Viral Haemorrhagic Fever, Not Otherwise Specified
Human Immunodeficiency Virus Infectious Disease

  • Hiv Infections
West Nile Fever
Dengue Hemorrhagic Fever

  • Severe Dengue

  • Dengue Haemorrhagic Fever

  • Dhf

  • Severe Dengue Haemorrhagic Fever

  • Severe Dengue Fever

  • Dengue Shock Syndrome
Argentine Hemorrhagic Fever

  • Argentinian Hemorrhagic Fever

  • Junin Hemorrhagic Fever

  • Hemorrhagic Fever, Argentinian

  • Ahf - [Argentinian Haemorrhagic Fever]

  • Argentine Haemorrhagic Fever

  • Junin Haemorrhagic Fever
Dengue Shock Syndrome

  • Dss
Tick-Borne Encephalitis

  • Siberian Tick-Borne Encephalitis

  • Encephalitis, Tick-Borne

  • Central European Encephalitis

  • Far Eastern Tbe

  • Russian Spring-Summer Encephalitis

  • Taiga Encephalitis

  • West-Siberian Encephalitis

  • Western European Tick-Borne Encephalitis

  • Tbe

  • Encephalitis Tick-Borne

  • Encephalitis, Central European

  • Encephalitis, Far Eastern Russian
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Coronavirus Infectious Disease
Factor Viii Deficiency

  • Autosomal Hemophilia A

  • Hemophilia A

  • Autosomal Factor Viii Deficiency

  • Classic Hemophilia A

  • Congenital Factor Viii Disorder

  • Subhemophilia

  • Factor 8 Deficiency, Congenital

  • Factor Viii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02797 CLEC4M Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLEC4M RGD RGD:1561466
Others CLEC4M NCBI