PROCR - protein C receptor Gene

Also Known as CCCA; EPCR; CCD41

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10544

About PROCR

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,171,096-35,216,259 (from NCBI)

This gene has 3 transcripts (splice variants), 119 orthologues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 14.7), fat (RPKM 10.7) and 24 other tissues.

Summary

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial Infection and has been associated with Cancer. [provided by RefSeq, Jul 2013]

PROCR Products (1)

mRNA Protein Name
NM_006404.5 NP_006395.2 endothelial protein C receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17299037 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of coagulation IMP
IMP: Inferred from mutant phenotype
19696402 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROCR Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (108 - 197)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

endothelial protein C receptor

  • APC receptor

PROCR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PROCR Q9UNN8 F2R Homo sapiens P25116
Anti Bait CoIP
17299037
Intra
PROCR Q9UNN8 F2R Homo sapiens P25116
Anti Bait CoIP
20826780
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PROCR Proteins

Cat. No. Product Name Accession Purity
HY-P70936 EPCR Protein, Human (HEK293, His) Q9UNN8 (S18-S210) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75247 EPCR Protein, Human (HEK293, hFc) Q9UNN8 (S18-T209) ≥ 95%, as determined by reducing SDS-PAGE.

PROCR Antibodies

Cat. No. Product Name Application Reactivity
HY-P86862 EPCR Antibody (YA6555) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Purpura Fulminans

  • Purpura Gangrenosa
Thrombophilia

  • Hypercoagulability State
Thrombosis

  • Thrombosis Of Blood Vessel
Antiphospholipid Syndrome

  • Antiphospholipid Antibody Syndrome

  • Hughes Syndrome

  • Familial Antiphospholipid Syndrome

  • Aps

  • Lupus Anticoagulant, Familial

  • Anti-Phospholipid Syndrome

  • Apls

  • Classic Apls

  • Classic Antiphospholipid Syndrome

  • Acromegaloid Facial Appearance Syndrome

  • Anticardiolipin Syndrome
Protein C Deficiency

  • Hereditary Thrombophilia Due To Protein C Deficiency

  • Proc Deficiency

  • Congenital Thrombotic Disease, Due To Protein C Deficiency
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Meningococcemia
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Thrombophilia Due To Thrombin Defect

  • Venous Thromboembolism

  • Venous Thrombosis

  • Thrombophilia Due To Factor 2 Defect

  • Thromboembolism

  • THPH1

  • Thromboembolism, Susceptibility To

  • Venous Thromboembolism, Susceptibility To

  • Venous Thrombosis, Protection Against

  • Prothrombin-Related Thrombophilia

  • Hyperprothrombinemia

  • Venous Thrombosis, Susceptibility To

  • Thrombophilia 1 Due To Thrombin Defect

  • F2-Related Thrombophilia

  • Factor Ii-Related Thrombophilia

  • Prothrombin 20210g>A Thrombophilia

  • Prothrombin G20210a Thrombophilia

  • Prothrombin Thrombophilia
Disseminated Intravascular Coagulation

  • Defibrination Syndrome

  • Dic

  • Diffuse Or Disseminated Intravascular Coagulation

  • Fibrinolytic Purpura

  • Consumption Coagulopathy

  • Diffuse Intravascular Coagulation

  • Dic - [Disseminated Intravascular Coagulation]

  • Disseminated Intravascular Coagulopathy

  • Fibrinolysis Nos

  • Thrombolytic Purpura
Melioidosis

  • Melioidosis, Susceptibility To

  • Acute And Fulminating Melioidosis

  • Nightcliff Gardener'S Disease

  • Pseudoglanders

  • Subacute And Chronic Melioidosis

  • Burkholderia Pseudomallei Infection

  • Whitmore Disease

  • Whitmore'S Disease

  • B Pseudomallei Infection

  • Epizootic Lymphangitis

  • Infection Due To Burkholderia Pseudomallei

  • Infection Due To Burkholderia Pseudomallei Nos

  • Infection Due To Malleomyces Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei Nos

  • Infection Due To Whitmore Bacillus

  • Stanton Disease
Beta-Thalassemia

  • Beta Thalassemia

  • Cooley'S Anemia

  • Mediterranean Anemia

  • Beta Thalassemia Intermedia

  • Erythroblastic Anemia

  • Thalassemia, Hispanic Gamma-Delta-Beta

  • Thalassemia Major

  • Thalassemia Minor

  • Beta-Plus-Thalassemia

  • Thalassemia, Beta

  • Beta Thalassemia Major

  • Beta Thalassemia Minor

  • Thalassemias, Beta-

  • Microcytemia, Beta Type

  • Thalassemia, Beta Type

  • B-THAL

  • Mediterranean Anaemia

  • Beta Thalassaemia Syndrome

  • Mediterranean Disease

  • Beta Thalassaemia Disease
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Parasitic Protozoa Infectious Disease

  • Protozoan Infections

  • Mastigophora Infectious Disease

  • Sarcomastigophora Infectious Disease
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Stroke, Ischemic

  • Cerebral Infarction

  • Stroke

  • Ischemic Stroke

  • Cerebrovascular Accident

  • Cerebral Infarction, Susceptibility To

  • Stroke, Ischemic, Susceptibility To

  • Cerebral Infarct

  • Ischemic Stroke, Susceptibility To

  • Stroke, Susceptibility To

  • Cva - Cerebral Infarction

  • ISCHSTR

  • Ischemic Cerebrovascular Accident
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11191 PROCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17840 Procr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24308 Procr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PROCR VGNC VGNC:69078
Mus musculus PROCR MGD MGI:104596
Rattus norvegicus PROCR RGD RGD:1305991
Canis familiaris PROCR VGNC VGNC:45008
Bos taurus PROCR VGNC VGNC:33359
Macaca mulatta PROCR VGNC VGNC:107919
Others PROCR NCBI