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NOXA1 - NADPH oxidase activator 1 Gene

Also Known as p51NOX; NY-CO-31; SDCCAG31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10811

About NOXA1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,423,393-137,434,406 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 4.2), stomach (RPKM 4.0) and 25 other tissues.

Summary

This gene encodes a protein which activates NADPH oxidases, Enzymes which catalyze a reaction generating Reactive Oxygen Species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

NOXA1 Products (3)

mRNA	Protein	Name
NM_001256067.2	NP_001242996.1	NADPH oxidase activator 1 isoform 2
NM_001256068.2	NP_001242997.1	NADPH oxidase activator 1 isoform 3
NM_006647.2	NP_006638.1	NADPH oxidase activator 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19755710	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16329988	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables superoxide-generating NADPH oxidase activator activity	IDA IDA: Inferred from direct assay	20609497	GOA
enables superoxide-generating NADPH oxidase activator activity	IMP IMP: Inferred from mutant phenotype	16636067	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	16636067	GOA
involved in regulation of respiratory burst	IMP IMP: Inferred from mutant phenotype	16636067	GOA
involved in superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	20609497	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NADPH oxidase complex	IDA IDA: Inferred from direct assay	16636067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOXA1 Protein Structure

TPR_2

PB1

SH3_1

0
100
200
300
400
483 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase activator 1	NCF2-like protein

NOXA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOXA1	Q86UR1	RIMBP3	Homo sapiens	Q9UFD9	Y2H Array	25416956
Intra	NOXA1	Q86UR1	NOXO1	Homo sapiens	Q8NFA2-3	Pull Down	23957209

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lung Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Lung
Granulomatous Disease, Chronic, Autosomal Recessive, 1	Chronic Granulomatous Disease Due To Deficiency Of Ncf-1 CGD1 Ncf1 Deficiency Soluble Oxidase Component Ii Deficiency Soc2 Deficiency P47-Phox Deficiency Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I Deficiency Of Neutrophil Cytosol Factor 1 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I Cgd, Autosomal Recessive Cytochrome B-Positive, Type I Granulomatous Disease, Chronic, Due To Ncf1 Deficiency Neutrophil Cytosol Factor 1 Deficiency Chronic Granulomatous Disease 1, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 1 Cdg1 Deficiency Of Ncf1 Deficiency Of P47-Phox Deficiency Of Soc2 Deficiency Of Soluble Oxidase Component Ii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I Chronic Granulomatous Disease Due To Ncf1 Deficiency
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Phagocyte Bactericidal Dysfunction	Phagocytic Dysfunction
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Granulomatous Disease, Chronic, X-Linked	CGDX Chronic Granulomatous Disease, X-Linked X-Linked Chronic Granulomatous Disease Cgd Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked Cdgx X-Linked Chronic Cytochrome B-Negative Granulomatous Disease Chronic Granulomatous Disease Cytochrome B-Negative X-Linked Chronic Granulomatous Disease Cytochrome B-Positive X-Linked Granulomatous Disease, Chronic, X-Linked, Variant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1435	NoxA1ds	Inhibitor	95.34%	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown
HY-RS09465	NOXA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21666	Noxa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28184	Noxa1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NOXA1	VGNC	VGNC:55664
Mus musculus	NOXA1	MGD	MGI:2449980
Rattus norvegicus	NOXA1	RGD	RGD:1306687
Bos taurus	NOXA1	VGNC	VGNC:32186
Macaca mulatta	NOXA1	VGNC	VGNC:75163
Felis catus	NOXA1	VGNC	VGNC:102956
Others	NOXA1	NCBI