CEACAM8 - CEA cell adhesion molecule 8 Gene

Also Known as CD67; CGM6; CD66b; NCA-95

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1088

About CEACAM8

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,580,243-42,594,924 (from NCBI)

This gene has 2 transcripts (splice variants), 571 orthologues and 24 paralogues. Restricted expression toward bone marrow (RPKM 58.6).

Summary

Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022]

CEACAM8 Products (1)

mRNA Protein Name
NM_001816.4 NP_001807.2 carcinoembryonic antigen-related cell adhesion molecule 8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11994468 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
26483485 GOA
Biological Process GO Annotation Evidence References Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
8776764 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8776764 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
25645918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM8 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (42 - 136)

Ig_3

Ig_3: Immunoglobulin domain (146 - 219)

Ig_2

Ig_2: Immunoglobulin domain (239 - 314)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

carcinoembryonic antigen-related cell adhesion molecule 8

  • CD67 antigen

CEACAM8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CEACAM8 P31997 CEACAM6 Homo sapiens P40199
Protein Array
21982860
Intra
CEACAM8 P31997 CEACAM6 Homo sapiens P40199
ITC
26483485
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM8 Proteins

Cat. No. Product Name Accession Purity
HY-P72133 CEACAM8/CD66b Protein, Human (His-SUMO) P31997 (Q35-D320) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72692 CEACAM8/CD66b Protein, Human (HEK293, His) P31997 (Q35-H141) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77629 CEACAM8/CD66b Protein, Human (285a.a, HEK293, His) P31997 (Q35-S319) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78893 CEACAM8/CD66b Protein, Human (Biotinylated, sf9, His-Avi) P31997 (Q35-S319) ≥ 95%, as determined by reducing SDS-PAGE.

CEACAM8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82326 CD66b Antibody (YA2071) WB Human
HY-P85003 CD66b Antibody (YA4695) ELISA, FC Human

Related Diseases

Diseases Alias
Paroxysmal Nocturnal Hemoglobinuria

  • Marchiafava-Micheli Disease

  • Pnh

  • Hemoglobinuria, Paroxysmal

  • Marchiafava-Micheli Syndrome

  • Paroxysmal Hemoglobinuria Nocturnal

  • Nocturnal Haemoglobinuria

  • Nocturnal Paroxysmal Haematuria

  • Nocturnal Paroxysmal Haemoglobinaemia
Hemoglobinuria
Reactive Arthritis

  • Postdysenteric Arthropathy

  • Reiter Disease

  • Pira

  • Reiter Syndrome

  • Reiters Syndrome

  • Arthritis, Reactive

  • Fiessinger Leroy Reiter Syndrome

  • Post-Bacterial Arthropathy

  • Reiter'S Disease

  • Post-Infectious Arthritis

  • Post-Infectious Reactive Arthropathy

  • Reiter'S Syndrome

  • Arthritis Urethritica

  • Fiessinger-Leroy Disease

  • Polyarthritis Enterica

  • Venereal Arthritis

  • Arthritis Reactive

  • Post-Dysenteric Arthropathy

  • Arthritis, Venereal
Endocarditis
Developmental And Epileptic Encephalopathy 38

  • DEE38

  • Epileptic Encephalopathy, Early Infantile, 38

  • Eiee38

  • Developmental And Epileptic Encephalopathy, 38

  • Glycosylphosphatidylinositol Biosynthesis Defect 23

  • Gpibd23

  • Early Infantile Epileptic Encephalopathy 38
Myelofibrosis

  • Primary Myelofibrosis

  • Agnogenic Myeloid Metaplasia

  • Idiopathic Myelofibrosis

  • Myeloid Metaplasia

  • Myelofibrosis With Myeloid Metaplasia

  • Osteomyelofibrosis

  • Megakaryocytic Myelosclerosis

  • Myelosclerosis

  • Chronic Idiopathic Myelofibrosis

  • Myelofibrosis, Idiopathic

  • Myelofibrosis With Myeloid Metaplasia, Somatic

  • Myelofibrosis, Somatic

  • Aleukemic Myelosis

  • Bone Marrow Fibrosis

  • MYELOF

  • MMM

  • Agnogenic Myeloid Metaplasia With Myelofibrosis

  • Ammm

  • Myelosclerosis With Myeloid Metaplasia

  • Myelofibrosis Nos
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02444 CEACAM8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990854 Anti-CEACAM1/3/5/6/8 Antibody (6G5j) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CEACAM8 MGD MGI:1891352
Others CEACAM8 NCBI