PLCD3 - phospholipase C delta 3 Gene

Also Known as PLC-delta-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113026

About PLCD3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,108,959-45,132,515 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 14 paralogues. Broad expression in colon (RPKM 22.8), urinary bladder (RPKM 21.5) and 20 other tissues.

Summary

This gene encodes a member of the Phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic CA(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several Phospholipids. [provided by RefSeq, Jul 2008]

PLCD3 Products (1)

mRNA Protein Name
NM_133373.5 NP_588614.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

PLCD3 Protein Structure

EF-hand_10

EF-hand_10: EF hand (201 - 250)

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (255 - 335)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (339 - 483)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (527 - 643)

C2

C2: C2 domain (661 - 750)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3

Related Diseases

Diseases Alias
Adult Pineal Parenchymal Tumor

  • Adult Pineal Parenchymal Neoplasm
Adult Pineoblastoma
Craniofacial Microsomia

  • Goldenhar Syndrome

  • Hemifacial Microsomia

  • Oculoauriculovertebral Spectrum

  • Oavs

  • Oculo-Auriculo-Vertebral Spectrum

  • CFM

  • Oav Dysplasia

  • Facioauriculovertebral Sequence

  • Fav Sequence

  • First And Second Branchial Arch Syndrome

  • Otomandibular Dysostosis

  • Hfm

  • Oculoauriculovertebral Dysplasia

  • Facio-Auriculo-Vertebral Spectrum

  • Facioauriculovertebral Dysplasia

  • Oculo-Auriculo-Vertebral Dysplasia

  • First Arch Syndrome

  • Oav Dysplasia

  • Goldenhar Disease

  • Expanded Spectrum Hemifacial Microsomia

  • Expanded Spectrum Of Hemifacial Microsomia

  • Oculoauriculovertebral Syndrome

  • Oavd

  • Asymmetric Hypoplasia Of Facial Structures

  • Auriculobranchiogenic Dysplasia

  • Fav

  • First And Second Pharyngeal Arch Syndromes

  • Goldenhar-Gorlin Syndrome

  • Lateral Facial Dysplasia

  • Oav Complex

  • Oral-Mandibular-Auricular Syndrome

  • Unilateral Intrauterine Facial Necrosis

  • Unilateral Mandibulofacial Dysostosis

  • Oav Spectrum

  • Oculoauricular Vertebral Dysplasia

  • Microsomia, Hemifacial

  • Goldenhar Syndrome With Ipsilateral Radial Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS21692 Plcd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10657 PLCD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28210 Plcd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLCD3 MGD MGI:107451
Bos taurus PLCD3 VGNC VGNC:32985
Rattus norvegicus PLCD3 RGD RGD:1310903
Macaca mulatta PLCD3 VGNC VGNC:99205
Felis catus PLCD3 VGNC VGNC:68897
Canis familiaris PLCD3 VGNC VGNC:44648
Others PLCD3 NCBI