Dnm1l - dynamin 1-like Gene

Also Known as DLP1; Drp1; Dnml1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114114

Summary

Enables BH2 domain binding activity; clathrin binding activity; and identical protein binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and synaptic vesicle recycling. Located in several cellular components, including Golgi membrane; perinuclear region of cytoplasm; and peroxisome. Is active in presynaptic endocytic zone membrane and synaptic vesicle membrane. Colocalizes with clathrin-coated pit and mitochondrial membrane. Biomarker of chronic kidney disease; dental fluorosis; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (Dynamin 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Dnm1l Products (1)

mRNA Protein Name
NM_053655.3 NP_446107.2 dynamin-1-like protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BH2 domain binding IPI
IPI: Inferred from physical interaction
23792689 RGD
enables clathrin binding IPI
IPI: Inferred from physical interaction
23792689 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
23658809 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18250306 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
20802490 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
23792689 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
23658809 RGD
involved in cellular response to lipid IEP
IEP: Inferred from expression pattern
18006463 RGD
involved in intracellular distribution of mitochondria IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17443673 RGD
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in negative regulation of mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in positive regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
17443673 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
17443673 RGD
involved in response to flavonoid IEP
IEP: Inferred from expression pattern
24637344 RGD
involved in response to hypobaric hypoxia IEP
IEP: Inferred from expression pattern
24637344 RGD
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
23792689 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
23792689 RGD
involved in synaptic vesicle recycling via endosome IMP
IMP: Inferred from mutant phenotype
23792689 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
9472031 RGD
NOT part of clathrin coat of trans-Golgi network vesicle IDA
IDA: Inferred from direct assay
9472031 RGD
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
23792689 RGD
located in cytosol IDA
IDA: Inferred from direct assay
9472031 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9472031 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
23792689 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9472031 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
12499366 RGD
NOT located in plasma membrane IDA
IDA: Inferred from direct assay
9472031 RGD
is active in presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
23792689 RGD
located in secretory vesicle IDA
IDA: Inferred from direct assay
9472031 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
23792689 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynamin-1-like protein

  • C-terminal region

  • N-terminal region

  • dynamin-like protein 1

  • dynamin-related protein 1

Dnm1l Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dnm1l O35303 Bcl2l1 Rattus norvegicus P53563-1
Anti Bait CoIP
23792689
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03904 DNM1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17698 Dnm1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24160 Dnm1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnm1l NCBI NCBI:10059