Chrna1 - cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) Gene

Also Known as Acra; Achr-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11435

Summary

This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]

Chrna1 Products (1)

mRNA Protein Name
NM_007389.5 NP_031415.2 acetylcholine receptor subunit alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to acetylcholine binding IGI
IGI: Inferred from genetic interaction
8910344 MGI
contributes to acetylcholine receptor activity IDA
IDA: Inferred from direct assay
8872460 MGI
contributes to acetylcholine-gated monoatomic cation-selective channel activity IGI
IGI: Inferred from genetic interaction
2383398 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21187406 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
2383398 MGI
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IPI
IPI: Inferred from physical interaction
8910344 MGI
located in cell surface IDA
IDA: Inferred from direct assay
21187406 MGI
located in membrane IDA
IDA: Inferred from direct assay
20053883 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
4781450 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
16203963 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12388596 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
4781450 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acetylcholine receptor subunit alpha

Recombinant Chrna1 Proteins

Cat. No. Product Name Accession Purity
HY-P72141 CHRNA1 Protein, Mouse (His) P04756 (S21-L230) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72142 CHRNA1 Protein, Mouse (His-SUMO) P04756 (S21-L230) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02665 CHRNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17513 Chrna1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23970 Chrna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna1 NCBI NCBI:1134