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SLITRK1 - SLIT and NTRK like family member 1 Gene

Also Known as TTM; LRRC12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114798

About SLITRK1

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:83,877,205-83,882,474 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues, 25 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 10.6).

Summary

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with Trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SLITRK1 Products (2)

mRNA	Protein	Name
NM_001281503.2	NP_001268432.1	SLIT and NTRK-like protein 1 precursor
NM_052910.2	NP_443142.1	SLIT and NTRK-like protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19640509	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	23990902	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	23345436	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	23345436	GOA
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	27273464	GOA
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23345436	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK1 Protein Structure

LRR_8

LRR_1

LRR_8

0
200
400
600
696 a.a.

Protein Preferred Names	Protein Names
SLIT and NTRK-like protein 1	leucine-rich repeat-containing protein 12

SLITRK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLITRK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76077	SLITRK1 Protein, Human (HEK293, His-Fc)	Q96PX8 (N18-S616)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P76078	SLITRK1 Protein, Human (HEK293, His)	Q96PX8 (N18-S616)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Chronic Tic Disorder	Chronic Motor Or Vocal Tic Disorder Tic Disorders Tic Disorder Tic Disorder Nos Tic Nos Tic Spasm Nos
Transient Tic Disorder
Tic Disorder	Tics Behavioral Tic
Color Agnosia
Deafness, Autosomal Dominant 33	DFNA33 Autosomal Dominant Nonsyndromic Deafness 33 Autosomal Dominant Deafness 33
Trichothiodystrophy 5, Nonphotosensitive	TTD5 Nonphotosensitive Trichothiodystrophy 5 Trichothiodystrophy 5, Non-Photosensitive
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Abcd Syndrome	ABCDS Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness
Echolalia
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13373	SLITRK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20219	Slitrk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26726	Slitrk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLITRK1	VGNC	VGNC:65454
Rattus norvegicus	SLITRK1	RGD	RGD:1308858
Mus musculus	SLITRK1	MGD	MGI:2679446
Bos taurus	SLITRK1	VGNC	VGNC:34962
Canis familiaris	SLITRK1	VGNC	VGNC:46506
Macaca mulatta	SLITRK1	VGNC	VGNC:77744
Others	SLITRK1	NCBI